12月17日担当の解剖学講座吉永です。
下記の論文をご紹介いたします。
https://www.nature.com/articles/s41467-025-61829-4
Zhou J, Vitali I, Roig-Puiggros S, Javed A, Cantando I, Puglisi M, Bezzi P, Jabaudon D, Mayer C, Bocchi R.Dual lineage origins contribute to neocortical astrocyte diversity.Nat Commun. 2025 Jul 30;16(1):6992.doi: 10.1038/s41467-025-61829-4. PMID: 40738880; PMCID: PMC12310952.
Astrocytes are not a uniform population but exhibit diverse morphological, molecular, and functional characteristics. However, how this diversity originates and becomes establishes during development, remains largely unknown. Here, using single-cell RNA sequencing and spatial transcriptomics, we identify five astrocyte subtypes with unique molecular features, spatial distributions and functions in the mouse neocortex and characterize essential regulators for their formation. Using TrackerSeq to trace clonally related astrocytes, we identify two distinct lineages that give rise to these five subtypes. One lineage derives from Emx1+ radial glial cells that initially generate neurons and later switch to astrocyte production. The other, with minimal neuronal output, predominantly produces a distinct subset of astrocytes marked by Olig2. Olig2 knockout disrupts lineage specification, leading to changes at molecular, morphological and functional levels. These findings shed light on the cellular mechanisms underlying astrocyte diversity, highlighting the presence of multiple radial glial cell subtypes responsible for generating cortical astrocyte subtypes.
どうぞよろしくお願いいたします。
吉永
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吉永怜史
Satoshi YOSHINAGA, M.D., Ph.D.
luehdorfia2006sy
syoshinaga
東京慈恵会医科大学解剖学講座助教*
慶應義塾大学医学部解剖学教室訪問助教**
*105-8461 東京都港区西新橋3-25-8
Dept. of Anatomy, The Jikei University School of Medicine
3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, JAPAN
PHONE: +81-3-3433-1111
FAX: +81-3-3433-2065
**160-8582 東京都新宿区信濃町35
Dept. of Anatomy, Keio University School of Medicine
35 Shinanomachi, Shinjuku, Tokyo 160-8582, JAPAN
PHONE: +81-3-5363-3743