薬理学講座の中村です。下記の論文を紹介します。
Maria Mancini, Takuya Hikima, Paul Witkovsky, Jyoti C. Patel, Dominic W.
Stone, Alison H. Affinati and Margaret E. Rice,
Leptin Activates Dopamine and GABA Neurons in the Substantia Nigra via
a Local Pars Compacta-Pars Reticulata Circuit., Journal of Neuroscience 21 May 2025, 45 (21) e1539242025
Abstract
Adipose-derived leptin contributes to energy homeostasis by balancing food intake and motor output, but how leptin acts in brain motor centers remains poorly understood. We investigated the influence of leptin on neuronal activity in two basal ganglia nuclei involved in motor control: the substantia nigra pars compacta (SNc) and pars reticulata (SNr). Using a mouse reporter line to identify cells expressing leptin
receptors (LepRs), we found that in both sexes, a majority of SNc dopamine neurons express a high level of LepR. Whole-cell recording in ex vivo midbrain slices from male wild-type mice showed that leptin activates SNc dopamine neurons directly and increases somatodendritic dopamine release. Although LepR expression in SNr GABA output neurons was low, leptin also activated these cells. Additional experiments showed that the influence of leptin on SNr neurons is indirect and involves D1 dopamine receptors and TRPC3 channels. Systemic administration of leptin to male mice increased locomotor activity, consistent with activation of dopamine neurons in the SNc coupled to previously reported amplification of axonal dopamine release by leptin in striatal slices. These findings indicate that in addition to managing energy homeostasis through its actions as a satiety hormone, leptin also
promotes axonal and somatodendritic dopamine release that can influence motor output.