野口（神経科学研究部訪問研究員/東京ガス・グループ産業医）です。
直前のご案内になってしまいましたが、当日は下記の論文を紹介させて頂く予定
です。よろしくお願い致します。
Abstract:
Does the brain track how fast our blood glucose is changing? Knowing
such a rate of change would enable the prediction of an upcoming state
and a timelier response to this new state. Hypothalamic arousal-
orchestrating hypocretin/orexin neurons (HONs) have been proposed to be
glucose sensors, yet whether they track glucose concentration (
proportional tracking) or rate of change (derivative tracking) is
unknown. Using simultaneous recordings of HONs and blood glucose in
behaving male mice, we found that maximal HON responses occur in
considerable temporal anticipation (minutes) of glucose peaks due to
derivative tracking. Analysis of >900 individual HONs revealed glucose
tracking in most HONs (98%), with derivative and proportional trackers
working in parallel, and many (65%) HONs multiplexed glucose and
locomotion information. Finally, we found that HON activity is important
for glucose-evoked locomotor suppression. These findings reveal a
temporal dimension of brain glucose sensing and link neurobiological and
algorithmic views of blood glucose perception in the brain’s arousal
orchestrators.