Ketogenic Diet Dampens Excitatory Neurotransmission by Shrinking
Synaptic Vesicle Pools<\/a><\/p>\n\n\n\nMarion I. Stunault, Pan-Yue Deng, Anjali Yadav, Erica M. Periandri,
\nFrancisca N. de Luna Vitorino, Michael B. Thomsen, Jasmin Sponagel,
\nAmelia J. Barfield, Renzelle J. Ponce, Layla Foroughi, Benjamin A.
\nGarcia, Gabor Egervari, Vitaly A. Klyachko, Ghazaleh Ashrafi<\/p>\n\n\n\n
Cell Reports 45, 116945 (2026)<\/p>\n\n\n\n
Abstract<\/p>\n\n\n\n
Ketogenic diet (KD) is used for the treatment of drug-resistant
\nchildhood epilepsy and has been proposed to improve outcomes in
\nneurodegenerative diseases. However, the mechanisms by which KD alters
\nbrain circuitry remain unclear. Here, we investigated the impact of KD
\non hippocampal function through integrative analysis of gene expression
\nand neurotransmission. We found that KD induces extensive
\ntranscriptional reprogramming, including altered expression of numerous
\nsynaptic genes. Proteomic and genomic profiling revealed significant
\nchanges in histone modifications, particularly at promoters of
\nKD-regulated genes. Electrophysiological recordings showed that KD
\nreduces excitatory synaptic gain and short-term plasticity at CA3-CA1
\nsynapses, dampening the summation of excitatory inputs and enhancing the
\nsummation of inhibitory inputs. These functional changes were driven, in
\npart, by a reduction in the readily releasable vesicle pool at
\nexcitatory synapses under KD. Together, our findings demonstrate that KD
\ndrives transcriptional remodeling of hippocampal circuits, leading to
\nsynaptic adaptations that may underlie its anti-epileptic and
\nneuroprotective effects.<\/p>\n\n\n\n
\u4f55\u5352\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002
\n\u85ac\u7406\u5b66\u8b1b\u5ea7\u3000\u5ddd\u6751\u5c06\u4ec1<\/p>\n","protected":false},"excerpt":{"rendered":"
11\u670811\u65e5\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002 \u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002 Ketogenic Diet Dampens Excitatory Neurotransmission by Shrinking Synaptic …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-617","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=617"}],"version-history":[{"count":2,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions"}],"predecessor-version":[{"id":620,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/617\/revisions\/620"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}