{"id":616,"date":"2026-11-03T07:46:21","date_gmt":"2026-11-02T22:46:21","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=616"},"modified":"2026-11-03T07:46:21","modified_gmt":"2026-11-02T22:46:21","slug":"2026-11-4-%e6%8b%85%e5%bd%93-%e4%b8%ad%e6%9d%91%e8%a1%8c%e5%ae%8f","status":"publish","type":"post","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=616","title":{"rendered":"2026-11-4 \u62c5\u5f53 \u4e2d\u6751\u884c\u5b8f"},"content":{"rendered":"<p>11\u67084\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<br \/>\n\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>Dos Santos et al. (2026)<br \/>\nSoluble \u03b12\u03b4-1, altered in disease CSF, modulates network homeostasis and<br \/>\nrescues deficits in a neuropsychiatric mouse model<br \/>\n<a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2026.02.004\">https:\/\/doi.org\/10.1016\/j.neuron.2026.02.004<\/a><\/p>\n<p>Summary<br \/>\nExcitation-inhibition (E\/I) balance depends on dynamic communication<br \/>\nbetween neuronal subtypes, potentially beyond classical<br \/>\nneurotransmission. While membrane-bound ion channels are essential for<br \/>\nneuronal function, their potential roles as extracellular regulators of<br \/>\nnetwork dynamics remain largely unexplored. Here, we identify a soluble<br \/>\nform of the voltage-gated Ca2+ channel subunit \u03b12\u03b4-1 in human<br \/>\ncerebrospinal fluid (CSF) and show that it acts as an activity-regulated<br \/>\nintercellular modulator of network homeostasis. Soluble \u03b12\u03b4-1 is reduced<br \/>\nin the CSF of individuals with schizophrenia (SZ). Its synthetic analog,<br \/>\nsynthetic ectodomain of Alpha2Delta-1 (SEAD1), modulates cortical<br \/>\nactivity by enhancing the function of parvalbumin-positive (PV+)<br \/>\ninterneurons and restoring E\/I balance. A single SEAD1 injection into<br \/>\nthe prefrontal cortex of a genetic mouse model of SZ reversed synaptic<br \/>\nand behavioral deficits, including memory and social impairments. These<br \/>\nfindings reveal soluble synaptic ectodomains as a previously<br \/>\nunderappreciated class of extracellular signaling molecules with<br \/>\ntherapeutic potential in neuropsychiatric disorders.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>11\u67084\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002 \u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002 Dos Santos et al. (2026) Soluble \u03b12\u03b4-1, altered in disease CSF, &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-616","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=616"}],"version-history":[{"count":0,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/616\/revisions"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=616"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=616"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}