{"id":601,"date":"2026-07-07T19:58:01","date_gmt":"2026-07-07T10:58:01","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=601"},"modified":"2026-07-07T19:58:01","modified_gmt":"2026-07-07T10:58:01","slug":"2026-7-8-%e6%8b%85%e5%bd%93-%e5%bf%97%e7%89%9f%e7%94%b0%e7%be%8e%e4%bd%90","status":"publish","type":"post","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=601","title":{"rendered":"2026-7-8 \u62c5\u5f53 \u5fd7\u725f\u7530\u7f8e\u4f50"},"content":{"rendered":"<p>7\u67088\u65e5\u306b\u62c5\u5f53\u3044\u305f\u3057\u307e\u3059\u3001\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u5fd7\u725f\u7530\u3067\u3059\u3002<br \/>\n\u660e\u65e5\u306f\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidationJacobsen et al., 2026 eLife 15<\/p>\n<ul>\n<li><a href=\"https:\/\/doi.org\/10.7554\/eLife.110252.1\">https:\/\/doi.org\/10.7554\/eLife.110252.1<\/a><\/li>\n<\/ul>\n<p>Abstract<br \/>\nRecent work shows that the brain\u2019s arousal system remains active during sleep, with rhythmiclocus coeruleus (LC) activity shaping sleep architecture and supporting memory consolidation. TheLC releases norepinephrine (NE) in infraslow (\u223c0.02 Hz) bouts that gate NREM sleep spindles.Here, we demonstrate that heart rate (HR) fluctuations during NREM are tightly phase-locked tothese NE rhythms, identifying the LC as a key driver of very-low-frequency HR variability (VLF-HRV), an understudied autonomic signal. Using optogenetics, transient LC inhibition blunts HRslowing, whereas LC activation produces rapid HR acceleration, directly linking LC output tocardiac control during sleep. We further show that infraslow HR variability is a cross-speciesmarker of spindle-dependent memory processing. In mice, the amplitude of HR decelerationsduring NREM predicts spindle activity and subsequent memory performance. Remarkably, humansleepers show the same pattern: stronger VLF-HR fluctuations during NREM correspond toincreased spindle expression and better overnight memory retention. These findings reveal amechanistic pathway through which LC activity modulates autonomic physiology during sleep andidentify infraslow HR variability as a non-invasive marker of brainstem function and memory-promoting sleep. Because LC degeneration occurs early in neurodegenerative disease, sleep-derived HR metrics may provide a scalable indicator of emerging neuromodulatory dysfunction.<\/p>\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n<p>\u5fd7\u725f\u7530\u7f8e\u4f50<br \/>\n\u3012105-8461\u3000\u6771\u4eac\u90fd\u6e2f\u533a\u897f\u65b0\u6a4b3-25-8<br \/>\n\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u3000\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8<br \/>\n\u96fb\u8a71\u30000570-053333\u3000\u5185\u7dda2396<\/p>\n","protected":false},"excerpt":{"rendered":"<p>7\u67088\u65e5\u306b\u62c5\u5f53\u3044\u305f\u3057\u307e\u3059\u3001\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u5fd7\u725f\u7530\u3067\u3059\u3002 \u660e\u65e5\u306f\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002 Noradrenergic infraslow rhythm during sleep is the critical lin&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-601","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/601","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=601"}],"version-history":[{"count":0,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/601\/revisions"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}