www.nature.com\/articles\/s41422-026-01227-7<\/a>
\n(\u5148\u982d\u306bh\u3092\u4ed8\u3051\u8db3\u3057\u3066\u304f\u3060\u3055\u3044)<\/p>\nAbstract
\nChronic pain affects over 20% of the global population, yet frontline
\ntreatments remain limited in efficacy and are often hampered by serious
\nside effects. In search of novel and effective neuromodulation
\nalternatives, we discovered that 40 Hz flickering light effectively
\nalleviates inflammatory and neuropathic pain in mice. We identified the
\nretina-central amygdala (CeA) pathway as a critical conduit for the
\nanalgesic effects of 40 Hz flickering light. Using circuit-specific
\nmanipulations, we demonstrated that activation of the retina-CeA pathway
\nis both sufficient to mimic and necessary to mediate the analgesic
\noutcomes of 40 Hz light stimulation. In terms of mechanism, we found
\nthat 40 Hz light flickering significantly increases extracellular
\nadenosine levels in the CeA. Local pharmacological blockade of
\nequilibrative nucleoside transporters prevented this adenosine increase
\nand abolished the analgesic effects of 40 Hz light flickering, whereas
\nfocal adenosine infusion phenocopied the light-induced analgesia. Both
\ninterventions required A2A receptor signaling to suppress nociceptive
\nresponses. Furthermore, we found that hyperalgesia could be destabilized
\nin the CeA and reversed by 40 Hz light stimulation or adenosine infusion,
\nmirroring memory reconsolidation processes and implicating the CeA as a
\nkey locus for pain memory erasure. Collectively, our findings
\ndemonstrate the multifaceted therapeutic benefits of 40 Hz light
\nflickering as a novel non-invasive approach for pain management and
\nreveal a distinct retina-CeA circuit and adenosine signaling mechanism
\nfor control of chronic pain and pain memory.<\/p>\n
\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n
\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66 \u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8
\n\u5409\u672c \u51cc<\/p>\n","protected":false},"excerpt":{"rendered":"
6\u670824\u65e5\u306eNeuroClub\u3092\u62c5\u5f53\u3057\u307e\u3059\u3001\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u5409\u672c\u3067\u3059\u3002 \u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002 40 Hz light flickering alleviates chronic pain via adenosin…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-599","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=599"}],"version-history":[{"count":0,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/599\/revisions"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}