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Morales I and Berridge KC. Optogenetic Hedonic Hotspots in the Abstract\uff1b \u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n \u91ce\u53e3\u3000\u6df3<\/p>\n","protected":false},"excerpt":{"rendered":" 6\/17\u62c5\u5f53\u306e\u91ce\u53e3\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8 \u8a2a\u554f\u7814\u7a76\u54e1\uff09\u3067\u3059\u3002 \u5f53\u65e5\u306f\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304f\u4e88\u5b9a\u3067\u3059\u3002 Morales I and Berridge KC. Optogenetic Hedonic Hotspots in …<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-594","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/594","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=594"}],"version-history":[{"count":1,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/594\/revisions"}],"predecessor-version":[{"id":598,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/594\/revisions\/598"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=594"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=594"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=594"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness \u201c
Liking\u201d. J Neurosci. 2026 Apr 22;46(16):e0865252026. doi: 10.1523\/
JNEUROSCI.0865-25.2026.
PMID: 41839573<\/a>
PDF\u306f\u3001\u3053\u3061\u3089\u3067\u3059\u3002<\/a>
<\/p>\n\n\n\n
\nHedonic hotspots are localized brain sites where appropriate
\nstimulations can amplify the hedonic impact of palatable tastes,
\nmeasured as increases in affective orofacial “liking” reactions to
\nsweetness in rodents. Previously, two cortical hedonic hotspots in the
\norbitofrontal cortex and insula were identified using opioid or orexin
\nmicroinjections as neurochemical manipulations. Here we used optogenetic
\nstimulation in male and female rats to independently confirm the sites
\nand boundaries of two cortical hedonic hotspots, as well as their
\nspecial hedonic enhancement functions. We report that channelrhodopsin
\nstimulations within the two hedonic hotspots of rostral orbitofrontal
\nand caudal insula each doubled the number of hedonic “liking” reactions
\nelicited by sucrose taste. Additionally, we confirmed that an
\nintervening suppressive hedonic coldstrip stretches between them, where
\nstimulation reduced “liking” reactions. In contrast to the localization
\nof hedonic hotspots for “liking” enhancement, motivational “wanting” for
\nreward, measured as laser self-stimulation, was mediated by more widely
\ndistributed cortical sites in both hotspots and coldstrip.
\nKeywords: insula; optogenetics; orbitofrontal cortex; reward; \u201cliking\u201d;
\n\u201cwanting\u201d.<\/p>\n\n\n\n