{"id":451,"date":"2025-08-01T15:56:44","date_gmt":"2025-08-01T06:56:44","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=451"},"modified":"2025-08-01T15:58:09","modified_gmt":"2025-08-01T06:58:09","slug":"%e7%ac%ac501%e5%9b%9e%e3%80%8c%e5%8c%bb%e5%ad%a6%e7%a0%94%e7%a9%b6%e3%81%ae%e5%9f%ba%e7%a4%8e%e3%82%92%e8%aa%9e%e3%82%8a%e5%90%88%e3%81%86%e9%9b%86%e3%81%84%e3%80%8d","status":"publish","type":"post","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=451","title":{"rendered":"2025-08-18 \u7b2c501\u56de\u300c\u533b\u5b66\u7814\u7a76\u306e\u57fa\u790e\u3092\u8a9e\u308a\u5408\u3046\u96c6\u3044\u300d"},"content":{"rendered":"\n<p>\u4e0b\u8a18\u306b\u3066\u3001\u7b2c501\u56de\u300c\u533b\u5b66\u7814\u7a76\u306e\u57fa\u790e\u3092\u8a9e\u308a\u5408\u3046\u96c6\u3044\u300d\u3092\u884c\u3044\u307e\u3059\u3002\u7686\u3055\u307e\u3054\u53c2\u52a0\u3044\u305f\u3060\u3051\u308c\u3070\u5e78\u3044\u3067\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u984c\u540d\uff1a Fast Mapping of Cortical Microcircuits with 2-Photon Optogenetics<br>\u6f14\u8005\uff1a Dr. P. Jesper Sj\u00f6str\u00f6m, Professor, McGill University<br>\u65e5\u6642\uff1a 2025\u5e748\u670818\u65e5\uff08\u6708\u66dc\u65e5\uff0918:00\uff5e19:00<br>\u5834\u6240\uff1a 2\u53f7\u99288\u968e802\u4f1a\u8b70\u5ba4<\/p>\n\n\n\n<p>\u3000Jesper Sj\u00f6str\u00f6m\u5148\u751f\u306f\u3001\u5927\u8133\u76ae\u8cea\u306e\u30b7\u30ca\u30d7\u30b9\u4f1d\u9054\u3068\u305d\u306e\u53ef\u5851\u6027\u306b\u95a2\u3059\u308b\u7814\u7a76\u3067\u6570\u591a\u304f\u306e\u9855\u8457\u306a\u696d\u7e3e\u3092\u6319\u3052\u3089\u308c\u3066\u304a\u308a\u3001\u73fe\u5728\u306f\u30ab\u30ca\u30c0\u30fb\u30de\u30ae\u30eb\u5927\u5b66\u533b\u5b66\u90e8\u6559\u6388\u3001\u306a\u3089\u3073\u306b\u540c\u5927\u5b66\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u6240\u9577\u3092\u52d9\u3081\u3066\u304a\u3089\u308c\u307e\u3059\u3002<br>\u3000\u672c\u8b1b\u6f14\u3067\u306f\u3001\uff12\u5149\u5b50\u52b1\u8d77\u9855\u5fae\u93e1\u3092\u99c6\u4f7f\u3057\u3066\u5927\u8133\u76ae\u8cea\u30cb\u30e5\u30fc\u30ed\u30f3\u9593\u306e\u7d50\u5408\u3092\u8a73\u7d30\u304b\u3064\u9ad8\u901f\u306b\u30de\u30c3\u30d4\u30f3\u30b0\u3059\u308b\u3001\u65b0\u305f\u306a\u624b\u6cd5\u300coptomapping\u300d\u306b\u3064\u3044\u3066\u3054\u7d39\u4ecb\u3044\u305f\u3060\u304d\u307e\u3059\u3002\u307e\u305f\u3001\u3053\u306e\u624b\u6cd5\u3092\u7528\u3044\u3066\u660e\u3089\u304b\u306b\u3055\u308c\u305f\u3001\u81ea\u9589\u75c7\u95a2\u9023\u75be\u60a3\u30e2\u30c7\u30eb\u306b\u304a\u3051\u308b\u795e\u7d4c\u56de\u8def\u306e\u7279\u5fb4\u306b\u3064\u3044\u3066\u3082\u304a\u8a71\u3057\u3044\u305f\u3060\u304f\u4e88\u5b9a\u3067\u3059\u3002\u5b66\u90e8\u5b66\u751f\u304b\u3089\u6559\u8077\u54e1\u307e\u3067\u3001\u5e83\u304f\u7686\u69d8\u306e\u3054\u53c2\u52a0\u3092\u304a\u5f85\u3061\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>Understanding cortical microcircuits is key to linking brain function with neurological and psychiatric disorders. We developed optomapping, a high-throughput 2-photon optogenetic method that we used to rapidly map mouse visual cortex synaptic connectivity and plasticity with cell type and layer resolution. We are next extending this approach to motor and prefrontal cortical areas and to autism-related disease models including Fragile X and Smith-Magenis syndromes, to reveal how altered microcircuit wiring contributes to neuropathology.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/the-innovation\/fulltext\/S2666-6758(24)00173-5\">Chou CYC, Wong HHW, Guo C, Boukoulou KE, Huang C, Jannat J, Klimenko T, Li VY, Liang TA, Wu VC &amp; Sj\u00f6str\u00f6m PJ: Principles of visual cortex excitatory microcircuit organization<\/a>. The Innovation (2025) 6(1):100735<\/p>\n\n\n\n<p>\u77f3\u5ddd\u592a\u90ce<br>\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u3000\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u4e0b\u8a18\u306b\u3066\u3001\u7b2c501\u56de\u300c\u533b\u5b66\u7814\u7a76\u306e\u57fa\u790e\u3092\u8a9e\u308a\u5408\u3046\u96c6\u3044\u300d\u3092\u884c\u3044\u307e\u3059\u3002\u7686\u3055\u307e\u3054\u53c2\u52a0\u3044\u305f\u3060\u3051\u308c\u3070\u5e78\u3044\u3067\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002 \u984c\u540d\uff1a Fast Mapping of Cortical Microcircuits with&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[6],"tags":[],"class_list":["post-451","post","type-post","status-publish","format-standard","hentry","category-announcement"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/451","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=451"}],"version-history":[{"count":3,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/451\/revisions"}],"predecessor-version":[{"id":454,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/451\/revisions\/454"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=451"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=451"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=451"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}