GABAergic neurons in central amygdala contribute to orchestrating
anxiety-like behaviors and breathing patterns.
Wang X, Bi S, Yue Z, Chen X, Liu Y, Deng T, Shao L, Jing X, Wang C, Wang
Y, He W, Yu H, Shi L, Yuan F, Wang S.
Nat Commun. 2025 Apr 14;16(1):3544. doi: 10.1038\/s41467-025-58791-6.<\/a>
PMID: 40229297<\/p>\n\n\n\n<\/p>\n\n\n\n
Abstract
Anxiety is characterized by dysregulated respiratory reactivity to
emotional stimuli. The central amygdala (CeA) is a pivotal structure
involved in processing emotional alterations, but its involvement in
orchestrating anxiety-like behaviors and specific breathing patterns
remains largely unexplored. Our findings demonstrate that the acute
restraint stress (ARS) induces anxiety-like behaviors in mice, marked by
prolonged grooming time and faster respiratory frequency (RF).
Conversely, silencing GABAergic CeA neurons reduces post-ARS anxiety-
like behaviors, as well as the associated increases in grooming time and
RF. In actively behaving mice, stimulation of GABAergic CeA neurons
elicits anxiety-like behaviors, concurrently prolongs grooming time,
accelerates RF through a CeA-thalamic paraventricular nucleus (PVT)
circuit. In either behaviorally quiescent or anesthetized mice,
stimulation of these neurons significantly increases RF but does not
induce anxiety-like behaviors through the CeA-lateral parabrachial
nucleus (LPBN) circuit. Collectively, GABAergic CeA neurons are
instrumental in orchestrating anxiety-like behaviors and breathing
patterns primarily through the CeA-PVT and CeA-LPBN circuits,
respectively.<\/p>\n","protected":false},"excerpt":{"rendered":"
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