Abstract<\/em><\/strong><\/p>\n\n\n\nChronic visceral pain (CVP) often accompanies emotional disorders.
However, the lack of suitable animal models has hindered research into
their underlying molecular and neural circuitry mechanisms. Early-life
stress is a key factor in developing both visceral hypersensitivity and
emotional disorders, yet its pathological mechanisms are not well
understood. This study showed that adult offspring of prenatal maternal
stress (PMS)-exposed mice exhibited visceral hypersensitivity and
anxiety-like behaviors. Glutamatergic neurons in the anterior
paraventricular thalamus (aPVT) responded to visceral pain, while those
in the posterior PVT (pPVT) were more responsive to anxiety. The aPVT-
basolateral amygdala (BLA) and pPVT-central amygdala (CeA) circuits
regulated CVP and anxiety, respectively. Notably, increased Cacna1e
expression in aPVT enhanced both visceral pain and anxiety, while Grin2a
upregulation in pPVT facilitated only anxiety. These findings highlight
the distinct roles of aPVTGlu-BLAGlu-CeAGABA and pPVTGlu-CeAGABA
circuits, providing insights for therapeutic approaches in CVP and
anxiety comorbidity.<\/p>\n","protected":false},"excerpt":{"rendered":"
6\u67084\u65e5\u306eNeuroClub\u3092\u62c5\u5f53\u3057\u307e\u3059\u3001\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8 \u6210\u7530\u3067\u3059\u3002\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002 The paraventricular thalamus mediates visceral pain and anxie…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-417","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=417"}],"version-history":[{"count":1,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/417\/revisions"}],"predecessor-version":[{"id":418,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/417\/revisions\/418"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}