\u62c5\u5f53\uff1a\u57fa\u76e4\u7814\u30fb\u5c71\u6fa4\u5148\u751f<\/p>\n\n\n\n
\u3044\u3064\u3082\u5927\u5909\u304a\u4e16\u8a71\u306b\u306a\u3063\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n
4\u670816\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587<\/a>\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304d\u307e\u3059\u3002<\/p>\n\n\n\n \u5b9c\u3057\u304f\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n\n\n\n Cell . 2025 Jan 23;188(2):484-500.e22.<\/p>\n\n\n\n Periodic ER-plasma membrane junctions support long-range Ca2+<\/sup> signal integration in dendrites<\/p>\n\n\n\n Lorena Benedetti<\/a> 1 <\/a><\/sup>, Ruolin Fan<\/a> 2 <\/a><\/sup>, Aubrey V Weigel<\/a> 1 <\/a><\/sup>, Andrew S Moore<\/a> 1 <\/a><\/sup>, Patrick R Houlihan<\/a> 1 <\/a><\/sup>, Mark Kittisopikul<\/a> 1 <\/a><\/sup>, Grace Park<\/a> 1 <\/a><\/sup>, Alyson Petruncio<\/a> 1 <\/a><\/sup>, Philip M Hubbard<\/a> 1 <\/a><\/sup>, Song Pang<\/a> 3 <\/a><\/sup>, C Shan Xu<\/a> 4 <\/a><\/sup>, Harald F Hess<\/a> 1 <\/a><\/sup>, Stephan Saalfeld<\/a> 1 <\/a><\/sup>, Vidhya Rangaraju<\/a> 2 <\/a><\/sup>, David E Clapham<\/a> 1 <\/a><\/sup>, Pietro De Camilli<\/a> 5 <\/a><\/sup>, Timothy A Ryan<\/a> 6 <\/a><\/sup>, Jennifer Lippincott-Schwartz<\/a> 7<\/a><\/sup><\/p>\n\n\n\n Affiliations<\/p>\n\n\n\n Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over macroscopic distances remain unclear. Here, we discovered a system of periodically arranged endoplasmic reticulum-plasma membrane (ER-PM) junctions tiling the plasma membrane of dendrites at \u223c1 \u03bcm intervals, interlinked by a meshwork of ER tubules patterned in a ladder-like array. Populated with Junctophilin-linked plasma membrane voltage-gated Ca2+<\/sup> channels and ER Ca2+<\/sup>-release channels (ryanodine receptors), ER-PM junctions are hubs for ER-PM crosstalk, fine-tuning of Ca2+<\/sup> homeostasis, and local activation of the Ca2+<\/sup>\/calmodulin-dependent protein kinase II. Local spine stimulation activates the Ca2+<\/sup> modulatory machinery, facilitating signal transmission and ryanodine-receptor-dependent Ca2+<\/sup> release at ER-PM junctions over 20 \u03bcm away. Thus, interconnected ER-PM junctions support signal propagation and Ca2+<\/sup> release from the spine-adjacent ER. The capacity of this subcellular architecture to modify both local and distant membrane-proximal biochemistry potentially contributes to dendritic computations.<\/p>\n\n\n\n Keywords: Ca(2+)\/calmodulin-dependent protein kinase II; CaMKII; Drosophila melanogaster; ER-PM junctions; Junctophilin; RyRs; VGCC; endoplasmic reticulum; hippocampal neurons; ryanodine receptors; voltage-gated calcium channels; volume electron microscopy.<\/p>\n","protected":false},"excerpt":{"rendered":" \u62c5\u5f53\uff1a\u57fa\u76e4\u7814\u30fb\u5c71\u6fa4\u5148\u751f \u3044\u3064\u3082\u5927\u5909\u304a\u4e16\u8a71\u306b\u306a\u3063\u3066\u304a\u308a\u307e\u3059\u3002 4\u670816\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304d\u307e\u3059\u3002 \u5b9c\u3057\u304f\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002 Cell . 2025 Jan 23;188(2):484-500.e22. Peri…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-398","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/398","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=398"}],"version-history":[{"count":1,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/398\/revisions"}],"predecessor-version":[{"id":399,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/398\/revisions\/399"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=398"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=398"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=398"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}