{"id":367,"date":"2025-02-18T03:28:59","date_gmt":"2025-02-17T18:28:59","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=367"},"modified":"2025-02-18T03:29:57","modified_gmt":"2025-02-17T18:29:57","slug":"2025-02-19","status":"publish","type":"post","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=367","title":{"rendered":"2025-02-19"},"content":{"rendered":"\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u3000\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u7d14\u5049\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<br><a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2024.09.014\">Central control of opioid-induced mechanical hypersensitivity and tolerance in mice.<br>Yin G, Duan K, Dong D, Du F, Guo C, Zhang C, Liu X, Sun Y, Huang T, Cui G, Cheng L.<br>Neuron. 2024 Dec 4;112(23):3897-3923.e10. doi: 10.1016\/j.neuron.2024.09.014. Epub 2024 Oct 14.PMID: 39406237<\/a><br><strong>Abstract<\/strong><br>Repetitive use of morphine (MF) and other opioids can trigger two major pain-related side effects: opioid-induced hypersensitivity (OIH) and analgesic tolerance, which can be subclassified as mechanical and thermal. The central mechanisms underlying mechanical OIH\/tolerance remain unresolved. Here, we report that a brain-to-spinal opioid pathway, starting from \u03bc-opioid receptor (MOR)-expressing neuron in the lateral parabrachial nucleus (lPBNMOR+) via dynorphin (Dyn) neuron in the paraventricular hypothalamic nucleus (PVHDyn+) to \u03ba-opioid receptor (KOR)-expressing GABAergic neuron in the spinal dorsal horn (SDHKOR-GABA), controls repeated systemic administration of MF-induced mechanical OIH and tolerance in mice. The above effect is likely mediated by disruption of dorsal horn gate control for MF-resistant mechanical pain via silencing of the Dyn-positive GABAergic neurons in the SDH (lPBNMOR+ \u2192 PVHDyn+ \u2192 SDHKOR-GABA \u2192 SDHDyn-GABA). Repetitive binding of MF to MORs during repeated MF administration disrupted the above circuits. Targeting the above brain-to-spinal opioid pathways rescued repetitive MF-induced mechanical OIH and tolerance.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u3000\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u7d14\u5049\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002Central control of opioid-induced mechanical hypersensitivity an&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-367","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=367"}],"version-history":[{"count":2,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/367\/revisions"}],"predecessor-version":[{"id":369,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/367\/revisions\/369"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}