Orexin neurons track temporal features of blood glucose in behaving mice.
Viskaitis P, Tesmer AL, Liu Z, Karnani MM, Arnold M, Donegan D, Bracey E,
\u00a0Grujic N, Patriarchi T, Peleg-Raibstein D, Burdakov D.
Nat Neurosci. 2024 Jul;27(7):1299-1308. doi: 10.1038\/s41593-024-01648-w.
Epub 2024 May 21. PMID: 38773350<\/a><\/p>\n\n\n\n<\/p>\n\n\n\n
Abstract: <\/strong>
Does the brain track how fast our blood glucose is changing? Knowing
such a rate of change would enable the prediction of an upcoming state
and a timelier response to this new state. Hypothalamic arousal-
orchestrating hypocretin\/orexin neurons (HONs) have been proposed to be
glucose sensors, yet whether they track glucose concentration (
proportional tracking) or rate of change (derivative tracking) is
unknown. Using simultaneous recordings of HONs and blood glucose in
behaving male mice, we found that maximal HON responses occur in
considerable temporal anticipation (minutes) of glucose peaks due to
derivative tracking. Analysis of >900 individual HONs revealed glucose
tracking in most HONs (98%), with derivative and proportional trackers
working in parallel, and many (65%) HONs multiplexed glucose and
locomotion information. Finally, we found that HON activity is important
for glucose-evoked locomotor suppression. These findings reveal a
temporal dimension of brain glucose sensing and link neurobiological and
algorithmic views of blood glucose perception in the brain\u2019s arousal
orchestrators.<\/p>\n","protected":false},"excerpt":{"rendered":"\u91ce\u53e3\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\/\u6771\u4eac\u30ac\u30b9\u30fb\u30b0\u30eb\u30fc\u30d7\u7523\u696d\u533b\uff09\u3067\u3059\u3002\u76f4\u524d\u306e\u3054\u6848\u5185\u306b\u306a\u3063\u3066\u3057\u307e\u3044\u307e\u3057\u305f\u304c\u3001\u5f53\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304f\u4e88\u5b9a\u3067\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002 Orexin neurons track tempo…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-337","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=337"}],"version-history":[{"count":1,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/337\/revisions"}],"predecessor-version":[{"id":338,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/337\/revisions\/338"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=337"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=337"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}