{"id":260,"date":"2024-11-06T14:03:29","date_gmt":"2024-11-06T05:03:29","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=260"},"modified":"2024-11-12T14:05:08","modified_gmt":"2024-11-12T05:05:08","slug":"2024-11-06","status":"publish","type":"post","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?p=260","title":{"rendered":"2024-11-06"},"content":{"rendered":"\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u3002<br>11\u67086\u65e5\u306eNC\u3067\u306f<a href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(24)00756-3\">\u4e0b\u8a18\u306e\u8ad6\u6587<\/a>\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<br><\/p>\n\n\n\n<p>Kainate receptors regulate synaptic integrity and plasticity by forming<br>a complex with synaptic organizers in the cerebellum.<br>Cell Reports, 2024, 43, 114427<br>Kakegawa et al<\/p>\n\n\n\n<p>Highlights<br>\u2022Kainate receptors (KARs) are expressed at climbing fiber (CF)-Purkinje<br>cell (PC) synapses<br>\u2022KARs regulate CF-PC synaptic integrity, plasticity, and motor learning<br>\u2022KARs bind C1ql1 via the amino-terminal domain to stabilize C1ql1 and<br>Bai3 at synapses<br>\u2022KARs stabilize synapses as a scaffold, independent of ionotropic or<br>metabotropic functions<\/p>\n\n\n\n<p>Summary<br>Kainate (KA)-type glutamate receptors (KARs) are implicated in various<br>neuropsychiatric and neurological disorders through their ionotropic and<br>metabotropic actions. However, compared to AMPA- and NMDA-type receptor<br>functions, many aspects of KAR biology remain incompletely understood.<br>Our study demonstrates an important role of KARs in organizing climbing<br>fiber (CF)-Purkinje cell (PC) synapses and synaptic plasticity in the<br>cerebellum, independently of their ion channel or metabotropic functions.<br>&nbsp;The amino-terminal domain (ATD) of the GluK4 KAR subunit binds to C1ql1,<br>&nbsp;provided by CFs, and associates with Bai3, an adhesion-type G protein-<br>coupled receptor expressed in PC dendrites. Mice lacking GluK4 exhibit<br>no KAR-mediated responses, reduced C1ql1 and Bai3 levels, and fewer CF-<br>PC synapses, along with impaired long-term depression and oculomotor<br>learning. Remarkably, introduction of the ATD of GluK4 significantly<br>improves all these phenotypes. These findings demonstrate that KARs act<br>as synaptic scaffolds, orchestrating synapses by forming a KAR-C1ql1-<br>Bai3 complex in the cerebellum.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u300211\u67086\u65e5\u306eNC\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002 Kainate receptors regulate synaptic integrity and plasticity by forminga co&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3],"tags":[],"class_list":["post-260","post","type-post","status-publish","format-standard","hentry","category-journal-club"],"jetpack_sharing_enabled":true,"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/260","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=260"}],"version-history":[{"count":1,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/260\/revisions"}],"predecessor-version":[{"id":261,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/posts\/260\/revisions\/261"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=260"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=260"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=260"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}