{"id":92,"date":"2024-10-02T21:54:00","date_gmt":"2024-10-02T12:54:00","guid":{"rendered":"https:\/\/neuroclub.jikei-neuroscience.com\/?page_id=92"},"modified":"2025-10-17T13:40:11","modified_gmt":"2025-10-17T04:40:11","slug":"2010-06-14%e3%81%8b%e3%82%892024-10-02%e3%81%be%e3%81%a7%e3%81%ae%e8%a8%98%e9%8c%b2","status":"publish","type":"page","link":"https:\/\/neuroclub.jikei-neuroscience.com\/?page_id=92","title":{"rendered":"2010\u304b\u30892023\u307e\u3067\u306e\u8a18\u9332"},"content":{"rendered":"\n<p>\uff08\u9014\u4e2d\u629c\u3051\u3066\u3044\u307e\u3059\u304c\u6f38\u6b21\u66f8\u304d\u8fbc\u307f\u307e\u3059\uff09<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.1avb7odjsu9g_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1avb7odjsu9g\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1avb7odjsu9g\"><\/a>2023-12-27<\/h3>\n\n\n\n<p>\u85ac\u7406\uff1a\u77f3\u5ddd\u592a\u90ce\u5148\u751f<\/p>\n\n\n\n<p>\u660e\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Fos\u306e\u767a\u73fe\u306f\u3001\u305d\u306e\u7d30\u80de\u306e\u767a\u706b\u3067\u306f\u306a\u304f\u3001mGluR\u306a\u3069\u306b\u3088\u308bGq\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u3060\u3068\u3044\u3046\u8ad6\u6587\uff08\u30d7\u30ec\u30d7\u30ea\u30f3\u30c8\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>Neuronal FOS reports synchronized activity of presynaptic neurons<\/p>\n\n\n\n<p>Margarita Anisimova, Paul J. Lamothe-Molina, Andreas Franzelin, Aman S. Aberra, Michael B. Hoppa, Christine E. Gee, Thomas G. Oertner<\/p>\n\n\n\n<p>bioRxiv 2023.09.04.556168; doi:&nbsp;<a href=\"https:\/\/doi.org\/10.1101\/2023.09.04.556168\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1101\/2023.09.04.556168<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.unbnhiidscz_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.unbnhiidscz\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.unbnhiidscz\"><\/a>2023-12-20<\/h3>\n\n\n\n<p>\u85ac\u7406\uff1a\u4e2d\u6751\u5148\u751f<\/p>\n\n\n\n<p>\u4eca\u9031\u306eNC\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Laboute et al, 2023<\/p>\n\n\n\n<p>Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR<\/p>\n\n\n\n<p>Science. 2023 Mar 31;379(6639):1352-1358. doi: 10.1126\/science.add7150.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.uz6nk3rcw045_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.uz6nk3rcw045\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.uz6nk3rcw045\"><\/a>2023-12-13<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u9ad8\u6a4b\u7531\u9999\u91cc\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u9031\u306eNeuroclub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Son H, Zhang Y, Shannonhouse J, Ishida H, Gomez R, Kim YS.&nbsp;<\/p>\n\n\n\n<p>Mast-cell-specific receptor mediates alcohol-withdrawal-associated headache in male mice.&nbsp;<\/p>\n\n\n\n<p>Neuron. 2023 Oct 26:S0896-6273(23)00752-3.&nbsp;<\/p>\n\n\n\n<p>doi: 10.1016\/j.neuron.2023.09.039.&nbsp;<\/p>\n\n\n\n<p>Epub ahead of print. PMID: 37909038.<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37909038\">https:\/\/pubmed.ncbi.nlm.nih.gov\/37909038<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.2l9n7ave9j1g_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.2l9n7ave9j1g\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.2l9n7ave9j1g\"><\/a>2023-12-06<\/h3>\n\n\n\n<p>\u6628\u5e74\u767a\u8868\u3057\u305f<\/p>\n\n\n\n<p>In vivo direct imaging of neuronal activity at high temporospatial resolution<\/p>\n\n\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abh4340\">https:\/\/www.science.org\/doi\/10.1126\/science.abh4340<\/a><\/p>\n\n\n\n<p>\u306e\u5f8c\u65e5\u8ac7\u3068\u3001\u3053\u306e\u8ad6\u6587\u306b\u95a2\u9023\u3057\u3066\u79c1\u304c\u6148\u6075\u533b\u5927\u3067\u884c\u3063\u3066\u3044\u308b\u6700\u65b0\u306e\u7814\u7a76\u6210\u679c\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u91e3\u6728\u6fa4<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.98thv4263bwe_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.98thv4263bwe\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.98thv4263bwe\"><\/a>2023-11-29<\/h3>\n\n\n\n<p>\u62c5\u5f53\u306e\u52a0\u85e4\u3067\u3059\uff0e\u6025\u907d\u4ea4\u4ee3\u3057\u305f\u306e\u3067\uff0c\u7d39\u4ecb\u3067\u304d\u308b\u6e96\u5099\u306e\u3042\u308b\u8ad6\u6587\u304c\u3042\u308a\u307e\u305b\u3093\uff0e<\/p>\n\n\n\n<p>\u5f53\u7814\u7a76\u5ba4\u306e\u5927\u5b66\u9662\u751f\uff0c\u5742\u7530\u65e9\u82d7\u3055\u3093\uff08\u76ae\u819a\u79d1\uff09\u306e\u8ad6\u6587\u6295\u7a3f\u76f4\u524d\u306e\u5185\u5bb9\u3092\u5742\u7530\u3055\u3093\u306b\u4ee3\u308f\u308a\u3054\u7d39\u4ecb\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>\u8ad6\u6587\u672a\u516c\u8868\u30c7\u30fc\u30bf\u3067\u3059\u304c\u3059\u3067\u306b\u56fd\u969b\u5b66\u4f1a\uff0c\u56fd\u5185\u5b66\u4f1a\u3067\u306f\u767a\u8868\u3057\u3066\u3044\u307e\u3059\uff0e<\/p>\n\n\n\n<p>\u30bf\u30a4\u30c8\u30eb\uff08\u4eee\uff09\u306f\uff0c\u300cUnbiased, model-free analysis of the neuronal activation by itch-induced scratching in the accumbens nucleus of the mice\u300d<\/p>\n\n\n\n<p>\u3067\u3059\uff0e\u3054\u610f\u898b\u306a\u3069\u304a\u805e\u304b\u305b\u304f\u3060\u3055\u3044\uff0e<\/p>\n\n\n\n<p>\u52a0\u85e4<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.rxbh4zlp2n70_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.rxbh4zlp2n70\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.rxbh4zlp2n70\"><\/a>2023-11-22<\/h3>\n\n\n\n<p>\u6b21\u56de\u300111\/22\u306eNeuroclub\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u30fb\u91ce\u53e3\uff08\u6771\u4eac\u30ac\u30b9\uff09\u3067<\/p>\n\n\n\n<p>\u3059\u3002\u5f53\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304f\u4e88\u5b9a\u3067\u3059\u3002\uff08Open Access\u3067\u3059\u306e\u3067\u3001\u4e0b<\/p>\n\n\n\n<p>\u8a18\u306eURL\u3088\u308a\u95b2\u89a7\u30fbPDF\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u304c\u53ef\u80fd\u3067\u3059\u3002\u3000\uff09<\/p>\n\n\n\n<p>\u2193<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41380-023-02131-x\">https:\/\/www.nature.com\/articles\/s41380-023-02131-x<\/a><\/p>\n\n\n\n<p>Disentangling the role of NAc D1 and D2 cells in hedonic eating<\/p>\n\n\n\n<p>Mathilde C. C. Guillaumin, Paulius Viskaitis, Eva Bracey, Denis Burdakov<\/p>\n\n\n\n<p>&amp; Daria Peleg-Raibstein<\/p>\n\n\n\n<p>Molecular Psychiatry volume 28, pages3531\u20133547 (2023)\u3000Aug;28(8):3531-<\/p>\n\n\n\n<p>3547. doi: 10.1038\/s41380-023-02131-x. PMID: 37402855 PMCID: PMC10618099<\/p>\n\n\n\n<p>Published: 04 July 2023&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.kphng68z6u3u_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kphng68z6u3u\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kphng68z6u3u\"><\/a>2023-11-08<\/h3>\n\n\n\n<p>11\u67088\u65e5\uff08\u6c34\uff092023\u5e74\u3000NCJC\u62c5\u5f53\u306e\u4e0a\u5712\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306f\u79c1\u305f\u3061\u304c\u884c\u3063\u3066\u3044\u308b\u6f22\u65b9\u85ac\u306e\u4f5c\u7528\u6a5f\u5e8f\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u3001\u30bf\u30fc\u30b2\u30c3\u30c8\u3092 TREK-1 K channel \u306b\u7d5e\u3063\u305f\u7814\u7a76\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>TREK-1 K channel\u306f\u73fe\u5728\u3001\u3046\u3064\u75c5\u306e\u5275\u85ac\u30bf\u30fc\u30b2\u30c3\u30c8\u3068\u3057\u3066\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u5206\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u53c2\u8003\u8ad6\u6587\u3068\u3057\u3066\u3001TREK-1 K channel\u3092\u542b\u3080\u3000K2P channel family\u306b\u3064\u3044\u3066\u8a00\u53ca\u3057\u3066\u3044\u308b\u7dcf\u8aac\u3092\u63d0\u793a\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.mxq7qkkitp65_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mxq7qkkitp65\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mxq7qkkitp65\"><\/a>2023-10-25<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8 \u5927\u5b66\u96624\u5e74\u306e\u4f50\u85e4\u5948\u4fdd\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Cardiogenic control of affective behavioural state.<\/p>\n\n\n\n<p>Hsueh B, Chen R, Jo Y, Tang D, Raffiee M, Kim YS, Inoue M, Randles S, Ramakrishnan C, Patel S, Kim DK, Liu TX, Kim SH, Tan L, Mortazavi L, Cordero A, Shi J, Zhao M, Ho TT, Crow A, Yoo AW, Raja C, Evans K, Bernstein D, Zeineh M, Goubran M, Deisseroth K.<\/p>\n\n\n\n<p>Nature. 2023 Mar;615(7951):292-299. doi: 10.1038\/s41586-023-05748-8. Epub 2023 Mar 1.<\/p>\n\n\n\n<p>PMID: 36859543<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.w6bso4yyo06p_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.w6bso4yyo06p\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.w6bso4yyo06p\"><\/a>2023-10-18<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u7fbd\u7530\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u660e\u65e5\u300110\u670818\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Pang, J. C., Aquino, K. M., Oldehinkel, M., Robinson, P. A., Fulcher, B. D., Breakspear, M., &amp; Fornito, A. (2023).&nbsp;<\/p>\n\n\n\n<p>Geometric constraints on human brain function. Nature, 1-9.<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41586-023-06098-1\">https:\/\/doi.org\/10.1038\/s41586-023-06098-1<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.m33jsolmftz_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m33jsolmftz\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m33jsolmftz\"><\/a>2023-10-11<\/h3>\n\n\n\n<p>\u57fa\u76e4\u7814\u7a76\u65bd\u8a2d\u306e\u5c71\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>10\u670811\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>&nbsp;Heart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2<\/p>\n\n\n\n<p>Haikel Dridi et al<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<strong>37429912<\/strong><\/li>\n\n\n\n<li>PMCID:&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc10400432\/\" target=\"_blank\" rel=\"noreferrer noopener\">PMC10400432<\/a><\/li>\n\n\n\n<li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s41593-023-01377-6\" target=\"_blank\" rel=\"noreferrer noopener\">10.1038\/s41593-023-01377-6<\/a><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.ihxdajp6yo51_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ihxdajp6yo51\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ihxdajp6yo51\"><\/a>2023-10-04<\/h3>\n\n\n\n<p>\u89e3\u5256\u5b66\u8b1b\u5ea7\u306e\u4e45\u4fdd\u5065\u4e00\u90ce\u3067\u3059\u3002<\/p>\n\n\n\n<p>10\u67084\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36280751\/\" target=\"_blank\" rel=\"noreferrer noopener\">Induced pluripotent stem cell-derived astrocytes from patients with schizophrenia exhibit an inflammatory phenotype that affects vascularization.<\/a><\/p>\n\n\n\n<p>Trindade P, et al. Mol Psychiatry. 2023. PMID: 36280751<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41380-022-01830-1\">https:\/\/www.nature.com\/articles\/s41380-022-01830-1<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.pom6j0p85ad7_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pom6j0p85ad7\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pom6j0p85ad7\"><\/a>2023-09-27<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u5ba4\u306e\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u3067\u3059\u3002<\/p>\n\n\n\n<p>9\u670827\u65e5\u306eNeuroClub\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Parabrachial Nucleus Activity in Nociception and Pain in Awake Mice.<\/p>\n\n\n\n<p>Smith JA, Ji Y, Lorsung R, Breault MS, Koenig J, Cramer N, Masri R, Keller A.<\/p>\n\n\n\n<p>J Neurosci. 2023 Aug 2;43(31):5656-5667. doi: 10.1523\/JNEUROSCI.0587-23.2023. Epub 2023 Jul 14.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.f1icub1r0tk4_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.f1icub1r0tk4\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.f1icub1r0tk4\"><\/a>2023-09-20<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u77f3\u5ddd\u592a\u90ce\uff08\u85ac\u7406\u5b66\u8b1b\u5ea7\uff09&nbsp;<\/p>\n\n\n\n<p>Azcorra M, Gaertner Z, Davidson C, He Q, Kim H, Nagappan S, Hayes CK, Ramakrishnan C, Fenno L, Kim YS, Deisseroth K, Longnecker R, Awatramani R, Dombeck DA.<\/p>\n\n\n\n<p>Unique functional responses differentially map onto genetic subtypes of dopamine neurons. Nat Neurosci. 2023 Aug 3. (Open access)<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41593-023-01401-9\">https:\/\/www.nature.com\/articles\/s41593-023-01401-9<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.s8ejzv1w29xa_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.s8ejzv1w29xa\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.s8ejzv1w29xa\"><\/a>2023-09-13<\/h3>\n\n\n\n<p>\u56fd\u885b\u7814\u85ac\u7406\u306e\u9ad8\u6a4b\u83ef\u5948\u5b50\u3067\u3059\uff0e<\/p>\n\n\n\n<p>\u4eca\u9031\u7d39\u4ecb\u4e88\u5b9a\u306e\u8ad6\u6587\u3092\u9001\u4ed8\u81f4\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>\u4f55\u5352\uff0c\u5b9c\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>Social deprivation induces astrocytic TRPA1-GABA suppression of hippocampal circuits.<\/p>\n\n\n\n<p>Y. T. Cheng, J. Woo, E. Luna-Figueroa, E. Maleki, A. S. Harmanci and B. Deneen<\/p>\n\n\n\n<p>Neuron 2023 Vol. 111 Issue 8 Pages 1301-1315 e5<\/p>\n\n\n\n<p>Accession Number: 36787749 PMCID: PMC10121837 DOI: 10.1016\/j.neuron.2023.01.015<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.zhqjgpid152o_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.zhqjgpid152o\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.zhqjgpid152o\"><\/a>2023-09-06<\/h3>\n\n\n\n<p>\u89e3\u5256\u5b66\u8b1b\u5ea7\u306e\u5409\u6c38\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u9031\u6c34\u66dc\u65e5\u306eNeuroclub\u3067\u306f\u3001\u3064\u304e\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002\u306a\u306b\u3068\u305e\u3069\u3046\u305e\u3001\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-40743-7\">https:\/\/www.nature.com\/articles\/s41467-023-40743-7<\/a><\/p>\n\n\n\n<p>Mangoni, D., Simi, A., Lau, P.&nbsp;<em>et al.<\/em>&nbsp;LINE-1 regulates cortical development by acting as long non-coding RNAs.&nbsp;<em>Nat Commun<\/em>&nbsp;<strong>14<\/strong>, 4974 (2023).<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.7pph6ktisnoe_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7pph6ktisnoe\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7pph6ktisnoe\"><\/a>2023-07-26<\/h3>\n\n\n\n<p>7\u670826\u65e5\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/journals.physiology.org\/doi\/full\/10.1152\/jn.00124.2023\">https:\/\/journals.physiology.org\/doi\/full\/10.1152\/jn.00124.2023<\/a><\/p>\n\n\n\n<p>J Neurophysiol 129: 1423\u20131433, 2023.<\/p>\n\n\n\n<p>doi:10.1152\/jn.00124.2023<\/p>\n\n\n\n<p>Antiseizure effect of 2-deoxyglucose is not dependent on the presynaptic<\/p>\n\n\n\n<p>vacuole ATP pump or the somatic ATP-sensitive K+ channel<\/p>\n\n\n\n<p>Li-Rong Shao, Remi Janicot, and Carl E. Stafstrom&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.lqm57b6buibw_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lqm57b6buibw\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lqm57b6buibw\"><\/a>2023-07-19<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u56fd\u7acb\u533b\u85ac\u54c1\u98df\u54c1\u885b\u751f\u7814\u7a76\u6240\u3000\u85ac\u7406\u90e8\u306e\u6700\u4e0a<\/p>\n\n\n\n<p>Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration<\/p>\n\n\n\n<p>Beatrice Paola Festa , Farah H Siddiqi , Maria Jimenez-Sanchez , Hyeran Won , Matea Rob , Alvin Djajadikerta , Eleanna Stamatakou , David C Rubinsztein<\/p>\n\n\n\n<p>Neuron 2023 111 (13) 2021-2037. e12.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627323002684?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0896627323002684?via%3Dihub<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.onwib2pye3bp_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.onwib2pye3bp\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.onwib2pye3bp\"><\/a>2023-07-05<\/h3>\n\n\n\n<p>7\u67085\u65e5\u306eNeuroClub\u3092\u62c5\u5f53\u3044\u305f\u3057\u307e\u3059\u3001\u4e5d\u5dde\u5927\u5b66\u85ac\u7406\u5b66\u5206\u91ce \u535a\u58eb\u8ab2\u7a0b1\u5e74\u306e\u5185\u5c71\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A shift in the mechanisms controlling hippocampal engram formation during brain maturation.&nbsp;<\/p>\n\n\n\n<p>Ramsaran AI, Wang Y, Golbabaei A, Aleshin S, de Snoo ML, Yeung BA, Rashid AJ, Awasthi A, Lau J, Tran LM, Ko SY, Abegg A, Duan LC, McKenzie C, Gallucci J, Ahmed M, Kaushik R, Dityatev A, Josselyn SA, Frankland PW.&nbsp;<\/p>\n\n\n\n<p>Science. 2023 May 5;380(6644):543-551. doi: 10.1126\/science.ade6530. Epub 2023 May 4. PMID: 37141366.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ade6530#acknowledgments\">https:\/\/www.science.org\/doi\/10.1126\/science.ade6530#acknowledgments<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.s5q5icrdiddw_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.s5q5icrdiddw\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.s5q5icrdiddw\"><\/a>2023-06-28<\/h3>\n\n\n\n<p>6\u670828\u65e5\u306eNeuroClub\u3092\u62c5\u5f53\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3001\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u6749\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Parabrachial tachykinin1-expressing neurons involved in state-dependent breathing control.<\/p>\n\n\n\n<p>Arthurs JW, Bowen AJ, Palmiter RD, Baertsch NA.<\/p>\n\n\n\n<p>Nat Commun. 2023 Feb 21;14(1):963. doi: 10.1038\/s41467-023-36603-z.<\/p>\n\n\n\n<p>PMID: 36810601<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-36603-z\">https:\/\/www.nature.com\/articles\/s41467-023-36603-z<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.lg8rsf71o19r_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lg8rsf71o19r\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lg8rsf71o19r\"><\/a>2023-06-21<\/h3>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u3002<\/p>\n\n\n\n<p>6\u670821\u65e5\u306eNC\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Young CSF restores oligodendrogenesis and memory in aged mice via Fgf17.<\/p>\n\n\n\n<p>Nature, 2022, Iram et al<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-022-04722-0\">https:\/\/www.nature.com\/articles\/s41586-022-04722-0<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.f8pe0cqca66k_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.f8pe0cqca66k\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.f8pe0cqca66k\"><\/a>2023-06-14<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u3000\u91e3\u6728\u6fa4\u3000\u3067\u3059&nbsp;.<\/p>\n\n\n\n<p>6\/14\uff08\u6c34\uff09\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Sleep fMRI with simultaneous electrophysiology at 9.4\u2009T in male mice<\/p>\n\n\n\n<p>Yu et al.&nbsp;<\/p>\n\n\n\n<p>Nat Comm. 2023 Mar 24;14(1):1651<\/p>\n\n\n\n<p>Open access\u3067\u3059\u306e\u3067\u3001\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-37352-9\">https:\/\/www.nature.com\/articles\/s41467-023-37352-9<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.qgkuiednraqp_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qgkuiednraqp\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qgkuiednraqp\"><\/a>2023-06-07<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u85ac\u7406\u5b66\u8b1b\u5ea7\u3000\u5fd7\u725f\u7530\u5148\u751f<\/p>\n\n\n\n<p>\u660e\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound.&nbsp;<\/p>\n\n\n\n<p>Yang et al. \u3000Nat Metab. 2023 May;5(5):789-803.<\/p>\n\n\n\n<p>Open access\u3067\u3059\u306e\u3067\u3001\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s42255-023-00804-z\">https:\/\/www.nature.com\/articles\/s42255-023-00804-z<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.jo5lt7sprjqu_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.jo5lt7sprjqu\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.jo5lt7sprjqu\"><\/a>2023-05-31<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u30fb\u52a0\u85e4<\/p>\n\n\n\n<p>\u4e0b\u8a18\u3092\u7d39\u4ecb\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>Khuong TM, Wang QP, Manion J, Oyston LJ, Lau MT, Towler H, Lin YQ, Neely GG. Nerve injury drives a heightened state of vigilance and neuropathic sensitization in Drosophila. Sci Adv. 2019 Jul 10;5(7):eaaw4099.<\/p>\n\n\n\n<p>doi: 10.1126\/sciadv.aaw4099. 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C, Borges-Merjane C, Le Monnier E,<\/p>\n\n\n\n<p>Nakamura Y, Sadakata T,&nbsp; Sanbo M, Hirabayashi M, Brose N, Jonas P,<\/p>\n\n\n\n<p>Shigemoto R.<\/p>\n\n\n\n<p>bioRxiv&nbsp;<a href=\"http:\/\/doi.org\/10.1101\/2022.10.28.514202\" target=\"_blank\" rel=\"noreferrer noopener\">doi.org\/10.1101\/2022.10.28.514202<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.lap0m974r7li_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lap0m974r7li\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lap0m974r7li\"><\/a>2023-05-10<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u91ce\u53e3\u3067\u3059\u3002<\/p>\n\n\n\n<p>5\u670810\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>FGF21 counteracts alcohol intoxication by activating the noradrenergic nervous system.<\/p>\n\n\n\n<p>Choi M, Schneeberger M, Fan W, Bugde A, Gautron L, Vale K, Hammer RE, Zhang Y, Friedman JM, Mangelsdorf DJ, Kliewer SA.<\/p>\n\n\n\n<p>Cell Metab. 2023 Mar 7;35(3):429-437.e5. doi: 10.1016\/j.cmet.2023.02.005.<\/p>\n\n\n\n<p>PMID: 36889282&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.kg8byr9vl4qx_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kg8byr9vl4qx\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kg8byr9vl4qx\"><\/a>2023-04-26<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u4e0a\u5712\u4fdd\u4ec1\u5148\u751f<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u30ec\u30d3\u30e5\u30fc\u3092\u30d9\u30fc\u30b9\u306b\u304a\u8a71\u3057\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u300c<strong>G\u86cb\u767d\u8cea\u5171\u5f79\u578b\u53d7\u5bb9\u4f53\uff08G protein-coupled receptor\uff1aGPCR\uff09\u306b\u304a\u3051\u308b\u53d7\u5bb9\u4f53\u30b7\u30b0\u30ca\u30eb\u306e\u30d0\u30a4\u30a2\u30b9\u30c9\u30a2\u30b4\u30cb\u30ba\u30e0\uff1a\u30aa\u30d4\u30aa\u30a4\u30c9\u03bc\u53d7\u5bb9\u4f53\u7814\u7a76\u304b\u3089\u306e\u30ec\u30c3\u30b9\u30f3\u300d<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.tich0mjxkrlk_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tich0mjxkrlk\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tich0mjxkrlk\"><\/a>2023-04-19<\/h3>\n\n\n\n<p>\u57fa\u76e4\u7814\u7a76\u65bd\u8a2d\u306e\u5c71\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>4\u670819\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Nature&nbsp; 2023 Mar;615(7954):884-891.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>PMID:&nbsp;<strong>36922596<\/strong><\/li>\n\n\n\n<li>PMCID:&nbsp;<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc10060165\/\" target=\"_blank\" rel=\"noreferrer noopener\">PMC10060165<\/a><\/li>\n\n\n\n<li>DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1038\/s41586-023-05828-9\" target=\"_blank\" rel=\"noreferrer noopener\">10.1038\/s41586-023-05828-9<\/a><\/li>\n<\/ul>\n\n\n\n<p><strong>Fast and sensitive GCaMP calcium indicators for imaging neural populations<\/strong><\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Zhang+Y&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Yan Zhang<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#equal-contrib-explanation\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>#<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=R%C3%B3zsa+M&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">M\u00e1rton R\u00f3zsa<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#equal-contrib-explanation\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>#<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-2\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;2&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Liang+Y&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Yajie Liang<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-4\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;4&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Bushey+D&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Daniel Bushey<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Wei+Z&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Ziqiang Wei<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Zheng+J&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Jihong Zheng<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Reep+D&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Daniel Reep<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Broussard+GJ&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Gerard Joey Broussard<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-5\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;5&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Tsang+A&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Arthur Tsang<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Tsegaye+G&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Getahun Tsegaye<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Narayan+S&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Sujatha Narayan<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-2\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;2&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Obara+CJ&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Christopher J Obara<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Lim+JX&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Jing-Xuan Lim<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Patel+R&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Ronak Patel<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Zhang+R&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Rongwei Zhang<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Ahrens+MB&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Misha B Ahrens<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Turner+GC&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Glenn C Turner<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-6\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;6&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-7\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;7&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Wang+SS&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Samuel S-H Wang<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-8\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;8&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Korff+WL&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Wyatt L Korff<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Schreiter+ER&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Eric R Schreiter<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Svoboda+K&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Karel Svoboda<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-9\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;9&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-10\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;10&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-11\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;11&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Hasseman+JP&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Jeremy P Hasseman<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-12\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;12&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-13\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;13&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Kolb+I&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Ilya Kolb<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Looger+LL&amp;cauthor_id=36922596\" target=\"_blank\" rel=\"noreferrer noopener\">Loren L Looger<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-14\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;14&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-15\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;15&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36922596\/#affiliation-16\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;16<\/sup><\/a><\/p>\n\n\n\n<p>Calcium imaging with protein-based indicators<sup>1,2<\/sup>&nbsp;is widely used to follow neural activity in intact nervous systems, but current protein sensors report neural activity at timescales much slower than electrical signalling and are limited by trade-offs between sensitivity and kinetics. Here we used large-scale screening and structure-guided mutagenesis to develop and optimize several fast and sensitive GCaMP-type indicators<sup>3-8<\/sup>. The resulting &#8216;jGCaMP8&#8217; sensors, based on the calcium-binding protein calmodulin and a fragment of endothelial nitric oxide synthase, have ultra-fast kinetics (half-rise times of 2 ms) and the highest sensitivity for neural activity reported for a protein-based calcium sensor. jGCaMP8 sensors will allow tracking of large populations of neurons on timescales relevant to neural computation.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.esqxawf3bfy8_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.esqxawf3bfy8\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.esqxawf3bfy8\"><\/a>2023-04-12<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u7fbd\u7530\uff08\u306f\u305f\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u660e\u65e5\u30014\u670812\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\uff08\u5909\u5206\uff09\u30d9\u30a4\u30ba\u75bc\u75db\u30e2\u30c7\u30eb\u306e\u5b9f\u9a13\uff08Human study)\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u671f\u5f85\u611f\u3068Agency(\u81ea\u5df1\u4e3b\u4f53\u6027)\u306b\u3088\u308b\u75bc\u75db\u5236\u5fa1\u304c\u3001\u30d9\u30a4\u30ba\u30e2\u30c7\u30eb\u306b\u304a\u3044\u3066\u306f\u3069\u306e\u30d1\u30e9\u30e1\u30fc\u30bf\u306b\u5bfe\u5fdc\u3059\u308b\u304b\u306b\u3064\u3044\u3066\u8abf\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Agency affects pain inference through prior shift as opposed to likelihood precision modulation in a Bayesian pain model<\/p>\n\n\n\n<p>Andreas Strube, Bj\u00f6rn Horing, Michael Rose, Christian B\u00fcchel<\/p>\n\n\n\n<p>Neuron. 2023 Apr 5;111(7):1136-1151.e7. doi: 10.1016\/j.neuron.2023.01.002.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.t27t23ym9bjr_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.t27t23ym9bjr\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.t27t23ym9bjr\"><\/a>2023-04-06<\/h3>\n\n\n\n<p>\u65b0\u5e74\u5ea6\u7b2c\uff11\u56de<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8 \u5927\u5b66\u9662\u751f\u306e\u4f50\u85e4\u5948\u4fdd\u5b50\u3067\u3059\u30024\u67085\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Identification of brain-to-spinal circuits controlling the laterality and duration of mechanical allodynia in mice<\/p>\n\n\n\n<p>Huo J, et al.\u3000Cell Rep. 2023\u3000PMID: 36952340<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.t85snd8xjl69_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.t85snd8xjl69\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.t85snd8xjl69\"><\/a>2023-03-29<\/h3>\n\n\n\n<p>\u62c5\u5f53\u306f\u4e45\u4fdd\u6559\u6388\u3067\u3059\uff0e<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.wwxfzu41f1ly_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.wwxfzu41f1ly\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.wwxfzu41f1ly\"><\/a>2023-03-22<\/h3>\n\n\n\n<p>WBC\u3067\u65e5\u672c\u304c\u6c7a\u52dd\u306b\u9032\u3093\u3060\u5834\u5408\u5ef6\u671f\u3068\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>\u6557\u9000\u3057\u305f\u5834\u5408\uff0c\u4e45\u4fdd\u6559\u6388\u304c\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>Hidenori Tabata, et al.,<\/p>\n\n\n\n<p>Erratic and blood vessel-guided migration of astrocyte progenitors in the cerebral cortex<\/p>\n\n\n\n<p>Nat Commun. 2022 Nov 2;13(1):6571.<\/p>\n\n\n\n<p>doi: 10.1038\/s41467-022-34184-x.<\/p>\n\n\n\n<p>\u30aa\u30fc\u30d7\u30f3\u30a2\u30af\u30bb\u30b9\uff1a<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41467-022-34184-x\">https:\/\/www.nature.com\/articles\/s41467-022-34184-x<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.br3xniol8xya_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.br3xniol8xya\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.br3xniol8xya\"><\/a>2023-03-08<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u6559\u5ba4\u306e\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u7d14\u5049\u304c\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain. Zhou H, Li M, Zhao R, Sun L, Yang G. Nat Neurosci. 2023 Jan 23. doi: 10.1038\/s41593-022-01250-y. Online ahead of print. PMID: 36690899<\/p>\n\n\n\n<p>\u8ad6\u6587\u306f<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41593-022-01250-y\">https:\/\/www.nature.com\/articles\/s41593-022-01250-y<\/a><\/p>\n\n\n\n<p>\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.g8vfmnb37gis_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.g8vfmnb37gis\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.g8vfmnb37gis\"><\/a>2023-03-01<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u85ac\u7406\u5b66\u8b1b\u5ea7\u30fb\u77f3\u5ddd<\/p>\n\n\n\n<p>Kannan M, Vasan G, Haziza S, Huang C, Chrapkiewicz R, Luo J, Cardin JA, Schnitzer MJ, Pieribone VA.<\/p>\n\n\n\n<p>Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types.<\/p>\n\n\n\n<p>Science. 2022 Nov 4;378(6619):eabm8797. doi: 10.1126\/science.abm8797.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.l8sh1ui73zzd_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l8sh1ui73zzd\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l8sh1ui73zzd\"><\/a>2023-02-22<\/h3>\n\n\n\n<p>2\/22\u306e\u62c5\u5f53\u306f\u89e3\u5256\u5b66\u8b1b\u5ea7\u306e\u5409\u6c38\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u305f\u3044\u3068\u8003\u3048\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>Batiuk MY, Tyler T, Dragicevic K, Mei S, Rydbirk R, Petukhov V, Deviatiiarov R, Sedmak D, Frank E, Feher V, Habek N, Hu Q, Igolkina A, Roszik L, Pfisterer U, Garcia-Gonzalez D, Petanjek Z, Adorjan I, Kharchenko PV, Khodosevich K. Upper cortical layer-driven network impairment in schizophrenia. Sci Adv. 2022 Oct 14;8(41):eabn8367. doi: 10.1126\/sciadv.abn8367. Epub 2022 Oct 12. PMID: 36223459; PMCID: PMC9555788.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.z2p7bq4d1010_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.z2p7bq4d1010\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.z2p7bq4d1010\"><\/a>2023-02-15<\/h3>\n\n\n\n<p>\u62c5\u5f53\uff1a\u56fd\u7acb\u885b\u7814\u30fb\u9ad8\u6a4b\u83ef\u5948\u5b50<\/p>\n\n\n\n<p><strong>Leucine 434 is essential for docosahexaenoic acid-induced augmentation of L-glutamate transporter current<\/strong><\/p>\n\n\n\n<p>Kanako Takahashi, Luying Chen, Misa Sayama, Mian Wu, Mariko Kato Hayashi, Tomohiko Irie, Tomohiko Ohwada, Kaoru Sato<\/p>\n\n\n\n<p>J Biol Chem 2022 Pages 102793<\/p>\n\n\n\n<p>Accession Number: 36509140 DOI: 10.1016\/j.jbc.2022.102793<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36509140\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/36509140<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.w1opivunqdc_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.w1opivunqdc\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.w1opivunqdc\"><\/a>2023-02-08<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u535a\u58eb\u8ab2\u7a0b\u5358\u4f4d\u53d6\u5f97\u8005\u306e\u5742\u7530\u65e9\u82d7\u3067\u3059\u3002<\/p>\n\n\n\n<p>2\u67088\u65e5(\u6c34)\u306e Neuroclub\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u4e0b\u8a18\u3088\u308a\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/t\/m4HgNgP4yzmANVqE\">https:\/\/www.dropbox.com\/t\/m4HgNgP4yzmANVqE<\/a><\/p>\n\n\n\n<p>Distinct Roles of Dopamine Receptor Subtypes in the Nucleus Accumbens during Itch Signal Processing<\/p>\n\n\n\n<p>Liang TY, Zhou H, Sun YG.&nbsp; J Neurosci. 2022 Nov 23;42(47):8842-8854. doi: 10.1523\/JNEUROSCI.0821-22.2022. Epub 2022 Oct 14. PMID: 36241382; PMCID: PMC9698675.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.fahc69yzx3k8_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.fahc69yzx3k8\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.fahc69yzx3k8\"><\/a>2023-02-01<\/h3>\n\n\n\n<p>2\u67081\u65e5\uff08\u6c34\uff09\u306eNCJC\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u9ad8\u6a4b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>The formalin test does not probe inflammatory pain but excitotoxicity in rodent skin.&nbsp;<\/p>\n\n\n\n<p>Hoffmann T, Klemm F, I Kichko T, Sauer SK, Kistner K, Riedl B, Raboisson P, Luo L, Babes A, Kocher L, Carli G, Fischer MJM, Reeh PW.&nbsp;<\/p>\n\n\n\n<p>Physiol Rep. 2022 Mar;10(6):e15194.&nbsp;<\/p>\n\n\n\n<p>doi: 10.14814\/phy2.15194.&nbsp;<\/p>\n\n\n\n<p>PMID: 35340127; PMCID: PMC8957662.<\/p>\n\n\n\n<p>\u8ad6\u6587\u306e\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u4ee5\u4e0b\u306eURL\u304b\u3089\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15194\">https:\/\/physoc.onlinelibrary.wiley.com\/doi\/10.14814\/phy2.15194<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.np7p3ipcyjpo_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.np7p3ipcyjpo\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.np7p3ipcyjpo\"><\/a>2023-01-25<\/h3>\n\n\n\n<p>1\u670825\u65e5\uff08\u6c34\uff09\u306eNCJC\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u6749\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain. Lin YL, Yang ZS, Wong WY, Lin SC, Wang SJ, Chen SP, Cheng JK, Lu H, Lien CC. Elife. 2022 Nov 15;11:e78610. doi: 0.7554\/eLife.78610. PMID: 36377439<\/p>\n\n\n\n<p>\u4e0b\u8a18\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/elifesciences.org\/articles\/78610\">https:\/\/elifesciences.org\/articles\/78610<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9665847\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9665847<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.y3kchdtoax61_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.y3kchdtoax61\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.y3kchdtoax61\"><\/a>2023-01-18<\/h3>\n\n\n\n<p>1\u670818\u65e5\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>J Neurophysiol. 2022 Dec 1;128(6):1566-1577. doi: 10.1152\/jn.00327.2022.<\/p>\n\n\n\n<p>Epub 2022 Nov 16.<\/p>\n\n\n\n<p>Enhanced burst discharges in the CA1 area of the immature versus adult<\/p>\n\n\n\n<p>hippocampus: patterns and cellular mechanisms<\/p>\n\n\n\n<p>Li-Rong Shao, F Edward Dudek&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.v0whe2gesj2u_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.v0whe2gesj2u\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.v0whe2gesj2u\"><\/a>2023-01-11<\/h3>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u3002<\/p>\n\n\n\n<p>1\u670811\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>OpenAccess\u3067\u3059\u306e\u3067\u3001\u5404\u81eaDL\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(22)00656-0\">https:\/\/www.cell.com\/neuron\/fulltext\/S0896-6273(22)00656-0<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/neuron\/pdfExtended\/S0896-6273(22)00656-0\">https:\/\/www.cell.com\/neuron\/pdfExtended\/S0896-6273(22)00656-0<\/a><\/p>\n\n\n\n<p>Synaptic-like axo-axonal transmission from striatal cholinergic<\/p>\n\n\n\n<p>interneurons onto dopaminergic fibers.<\/p>\n\n\n\n<p>Neuron, 2022, 110, p2949-2960<\/p>\n\n\n\n<p>Kramer et al<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.c3l2dyphffh3_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c3l2dyphffh3\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c3l2dyphffh3\"><\/a>2023-01-04<\/h3>\n\n\n\n<p>1\u67084\u65e5\uff08\u6c34\uff09\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u4e2d\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5c11\u3057\u524d\u306e\u8ad6\u6587\u3068\u306a\u308a\u307e\u3059\u304c\u4ee5\u4e0b\u3092\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Bossi et al.<\/p>\n\n\n\n<p>GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits<\/p>\n\n\n\n<p>Neuron. 2022 Aug 3;110(15):2438-2454.e8.&nbsp; Epub 2022 Jun 13.&nbsp;<\/p>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"h.5nikf941agcu_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5nikf941agcu\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5nikf941agcu\"><\/a>2022-12-28<\/h3>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u91ce\u53e3\uff08\u8a2a\u554f\u7814\u7a76\u54e1 \u6771\u4eac\u30ac\u30b9\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Dopamine subsystems that track internal states<\/p>\n\n\n\n<p>James C R Grove, Lindsay A Gray, Naymalis La Santa Medina, Nilla<\/p>\n\n\n\n<p>Sivakumar, Jamie S Ahn, Timothy V Corpuz, Joshua D Berke, Anatol C Kreitzer<\/p>\n\n\n\n<p>Nature. 2022 Aug;608(7922):374-380. doi: 10.1038\/s41586-022-04954-0.<\/p>\n\n\n\n<p>Epub 2022 Jul 13.<\/p>\n\n\n\n<p>PMID: 35831501 PMCID: PMC9365689 DOI: 10.1038\/s41586-022-04954-0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.kxjmbkf90quh_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kxjmbkf90quh\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kxjmbkf90quh\"><\/a>2022-12-21<\/h2>\n\n\n\n<p>12\u670821\u65e5\uff08\u6c34\uff09\u306eNCJC\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u91e3\u6728\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>In vivo direct imaging of neuronal activity at high temporospatial resolution<\/p>\n\n\n\n<p>Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee,Jongho Lee, Jeehyun Kwag, Jang-Yeon Park.<\/p>\n\n\n\n<p>Science.&nbsp; 2022 Oct 14;378(6616):160-168. doi: 10.1126\/science.abh4340.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.abh4340\">https:\/\/www.science.org\/doi\/10.1126\/science.abh4340<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.qps33mn3nywv_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qps33mn3nywv\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qps33mn3nywv\"><\/a>2022-12-14<\/h2>\n\n\n\n<p>12\u670814\u65e5\uff08\u6c34\uff09\u306eNCJC\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u9ad8\u6a4b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing.&nbsp;<\/p>\n\n\n\n<p>Allen HN, Chaudhry S, Hong VM, Lewter LA, Sinha GP, Carrasquillo Y, Taylor BK, Kolber BJ.&nbsp;<\/p>\n\n\n\n<p>Biol Psychiatry. 2022 Sep 16:S0006-3223(22)01591-8.<\/p>\n\n\n\n<p>doi: 10.1016\/j.biopsych.2022.09.010.<\/p>\n\n\n\n<p>Epub ahead of print.<\/p>\n\n\n\n<p>PMID: 36473754.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.32ptgigylo9_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.32ptgigylo9\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.32ptgigylo9\"><\/a>2022-12-07<\/h2>\n\n\n\n<p>12\u67087\u65e5\u62c5\u5f53\u306e\u5c71\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u5b9c\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5c71\u6fa4\u5fb7\u5fd7\u5b50(toshiko1998@jikei.ac.jp)<\/p>\n\n\n\n<p>\u57fa\u76e4\u7814\u7a76\u65bd\u8a2d\uff08\u5185\u7dda 2431)<\/p>\n\n\n\n<p>Nat Methods. 2022 Oct;19(10):1286-1294.<\/p>\n\n\n\n<p>doi: 10.1038\/s41592-022-01597-x. Epub 2022 Sep 22.&nbsp;PMID:&nbsp;<strong>36138174<\/strong><\/p>\n\n\n\n<p>A fluorescent sensor for real-time measurement of extracellular oxytocin dynamics in the brain<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Ino+D&amp;cauthor_id=36138174\" target=\"_blank\" rel=\"noreferrer noopener\">Daisuke Ino<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-1\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;1&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-2\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;2&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Tanaka+Y&amp;cauthor_id=36138174\" target=\"_blank\" rel=\"noreferrer noopener\">Yudai Tanaka<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3&nbsp;<\/sup><\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-4\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;4&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Hibino+H&amp;cauthor_id=36138174\" target=\"_blank\" rel=\"noreferrer noopener\">Hiroshi Hibino<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-5\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;5&nbsp;<\/sup><\/a>,&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&amp;size=100&amp;term=Nishiyama+M&amp;cauthor_id=36138174\" target=\"_blank\" rel=\"noreferrer noopener\">Masaaki Nishiyama<\/a><sup>&nbsp;<\/sup><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36138174\/#affiliation-3\" target=\"_blank\" rel=\"noreferrer noopener\"><sup>&nbsp;3<\/sup><\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.xnl9v3d9mr6l_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xnl9v3d9mr6l\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xnl9v3d9mr6l\"><\/a>2022-11-16<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u7d14\u5049\u304c\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation.<\/p>\n\n\n\n<p>Fern\u00e1ndez-Casta\u00f1eda A, et al,&nbsp; Cell. 2022 Jul 7;185(14):2452-2468.e16. doi:10.1016\/j.cell.2022.06.008. Epub 2022 Jun 13.<\/p>\n\n\n\n<p>PMID: 35768006&nbsp;<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, we explored the neurobiological effects of respiratory SARS-CoV-2 infection and found white-matter-selective microglial reactivity in mice and humans. Following mild respiratory COVID in mice, persistently impaired hippocampal neurogenesis, decreased oligodendrocytes, and myelin loss were evident together with elevated CSF cytokines\/chemokines including CCL11. Systemic CCL11 administration specifically caused hippocampal microglial reactivity and impaired neurogenesis. Concordantly, humans with lasting cognitive symptoms post-COVID exhibit elevated CCL11 levels. Compared with SARS-CoV-2, mild respiratory influenza in mice caused similar patterns of white-matter-selective microglial reactivity, oligodendrocyte loss, impaired neurogenesis, and elevated CCL11 at early time points, but after influenza, only elevated CCL11 and hippocampal pathology persisted. These findings illustrate similar neuropathophysiology after cancer therapy and respiratory SARS-CoV-2 infection which may contribute to cognitive impairment following even mild COVID.<\/p>\n\n\n\n<p>Keywords: COVID-19; H1N1 influenza; cognitive impairment; hippocampal neurogenesis; long COVID; microglia; myelin; neuroinflammation; oligodendrocytes.<\/p>\n\n\n\n<p>OPEN access\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u304b\u3089\u95b2\u89a7\u53ef\u80fd\u3067\u3059<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/action\/showPdf?pii=S0092-8674%2822%2900713-9\">https:\/\/www.cell.com\/action\/showPdf?pii=S0092-8674%2822%2900713-9<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.i6zl69ehi3z9_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.i6zl69ehi3z9\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.i6zl69ehi3z9\"><\/a>2022-11-09<\/h2>\n\n\n\n<p>\u89e3\u5256\u5b66\u8b1b\u5ea7\u306e\u4e45\u4fdd\u5065\u4e00\u90ce\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6b21\u56de\u300111\u67089\u65e5\u306eNeuroClub\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n\n\n\n<p>Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain<\/p>\n\n\n\n<p>Cell. 2022 Sep 29;185(20):3753-3769.e18. doi: 10.1016\/j.cell.2022.09.004.<\/p>\n\n\n\n<p>OPEN access\u306a\u306e\u3067\u3001\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u304b\u3089\u95b2\u89a7\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674%2822%2901126-6?_returnURL=https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0092867422011266?showall=true\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(22)01126-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867422011266%3Fshowall%3Dtrue<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.1arstg4ddq63_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1arstg4ddq63\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1arstg4ddq63\"><\/a>2022-11-02<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u7fbd\u7530\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u660e\u65e5\u300111\u67082\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways<\/p>\n\n\n\n<p>Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Yan-Jiao Wu, Xue Gu, Xin Yi, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X. Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li &amp; Tian-Le Xu<\/p>\n\n\n\n<p>Nat Commun. 2022 Sep 21;13(1):5540. doi: 10.1038\/s41467-022-33241-9.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.e729d4t9hr9y_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e729d4t9hr9y\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e729d4t9hr9y\"><\/a>2022-10-26<\/h2>\n\n\n\n<p>\u660e\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5c11\u3057\u53e4\u3044\u8ad6\u6587\u3067\u3059\u304c\u3001\u6765\u9031\u306e\u300c\u533b\u5b66\u7814\u7a76\u306e\u57fa\u790e\u3092\u8a9e\u308a\u5408\u3046\u96c6\u3044\u300d\u3067\u8b1b\u6f14\u3055\u308c\u308bWagner\u3055\u3093\u306e\u8ad6\u6587\u3067\u3059\u3002\u6765\u9031\u306e\u8b1b\u6f14\u3067\u306f\u3082\u3063\u3068\u65b0\u3057\u3044\u8a71\u3092\u3057\u3066\u304f\u308c\u308b\u3068\u601d\u3044\u307e\u3059\u306e\u3067\u3001\u305d\u306e\u4e88\u7fd2\u3092\u3057\u3066\u304a\u304d\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u8ad6\u6587\u306f\u4e0b\u8a18\u306epubmed\u30da\u30fc\u30b8\u306e\u30ea\u30f3\u30af\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3067\u304d\u307e\u3059\u306e\u3067\u3001\u5404\u81ea\u3067\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>Wagner MJ, Kim TH, Kadmon J, Nguyen ND, Ganguli S, Schnitzer MJ, Luo L. Shared Cortex-Cerebellum Dynamics in the Execution and Learning of a Motor Task. Cell. 2019 Apr 18;177(3):669-682.e24. doi: 10.1016\/j.cell.2019.02.019. Epub 2019 Mar 28.<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30929904\">https:\/\/pubmed.ncbi.nlm.nih.gov\/30929904<\/a><\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Throughout mammalian neocortex, layer 5 pyramidal (L5) cells project via the pons to a vast number of cerebellar granule cells (GrCs), forming a fundamental pathway. Yet, it is unknown how neuronal dynamics are transformed through the L5\u2192GrC pathway. Here, by directly comparing premotor L5 and GrC activity during a forelimb movement task using dual-site two-photon Ca2+ imaging, we found that in expert mice, L5 and GrC dynamics were highly similar. L5 cells and GrCs shared a common set of task-encoding activity patterns, possessed similar diversity of responses, and exhibited high correlations comparable to local correlations among L5 cells. Chronic imaging revealed that these dynamics co-emerged in cortex and cerebellum over learning: as behavioral performance improved, initially dissimilar L5 cells and GrCs converged onto a shared, low-dimensional, task-encoding set of neural activity patterns. Thus, a key function of cortico-cerebellar communication is the propagation of shared dynamics that emerge during learning.<\/p>\n\n\n\n<p>\u77f3\u5ddd\u592a\u90ce&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.hiik6utfhkyu_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.hiik6utfhkyu\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.hiik6utfhkyu\"><\/a>2022-10-19<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8 \u5927\u5b66\u96623\u5e74\u306e\u4f50\u85e4\u5948\u4fdd\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>10\u670819\u65e5\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Early life pain experience changes adult functional pain connectivity in the rat somatosensory and the medial prefrontal cortex.<\/p>\n\n\n\n<p>Chang P, et al. J Neurosci. 2022. PMID: 36192150<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.4wcs9v3wrs6a_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.4wcs9v3wrs6a\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.4wcs9v3wrs6a\"><\/a>2022-10-12<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u89e3\u5256\u5b66\u8b1b\u5ea7\u30fb\u5409\u6c38&nbsp;<\/p>\n\n\n\n<p>Vision-dependent specification of cell types and function in the developing cortex<\/p>\n\n\n\n<p>Sarah Cheng, Salwan Butrus, Liming Tan, Runzhe Xu, Srikant Sagireddy, Joshua T Trachtenberg, Karthik Shekhar, S Lawrence Zipursky<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.cell.2021.12.022\">https:\/\/doi.org\/10.1016\/j.cell.2021.12.022<\/a><\/p>\n\n\n\n<p>Cell 2022 Jan 20;185(2):311-327.e24.doi: 10.1016\/j.cell.2021.12.022.<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>The role of postnatal experience in sculpting cortical circuitry, while long appreciated, is poorly understood at the level of cell types. We explore this in the mouse primary visual cortex (V1) using single-nucleus RNA sequencing, visual deprivation, genetics, and functional imaging. We find that vision selectively drives the specification of glutamatergic cell types in upper layers (L) (L2\/3\/4), while deeper-layer glutamatergic, GABAergic, and non-neuronal cell types are established prior to eye opening. L2\/3 cell types form an experience-dependent spatial continuum defined by the graded expression of \u223c200 genes, including regulators of cell adhesion and synapse formation. One of these genes, Igsf9b, a vision-dependent gene encoding an inhibitory synaptic cell adhesion molecule, is required for the normal development of binocular responses in L2\/3. In summary, vision preferentially regulates the development of upper-layer glutamatergic cell types through the regulation of cell-type-specific gene expression programs.<\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u75bc\u75db\u5236\u5fa1\u7814\u7a76\u8b1b\u5ea7 \u7279\u4efb\u6559\u6388&nbsp;\u4e0a\u5712 \u4fdd\u4ec1 (Yasuhito Uezono) M.D., Ph.D.<\/p>\n\n\n\n<p>Distinct conformations of GPCR\u2013\u03b2-arrestin complexes<\/p>\n\n\n\n<p>mediate desensitization, signaling, and endocytosis<\/p>\n\n\n\n<p>Thomas J. Cahill IIIa,b,1, Alex R. B. Thomsena,1, Jeffrey T. Tarraschc,d, Bianca Plouffee, Anthony H. Nguyena,f, Fan Yangg, Li-Yin Huanga, Alem W. Kahsaia, Daniel L. Bassonih, Bryant J. Gavinoh, Jane E. Lamerdinh, Sarah Triesti,j,<\/p>\n\n\n\n<p>Arun K. Shuklaa,2, Benjamin Bergerb, John Little IVb, Albert Antarb, Adi Blancb, Chang-Xiu Qug, Xin Chenk,<\/p>\n\n\n\n<p>Kouki Kawakamil, Asuka Inouel,m, Junken Aokil,n, Jan Steyaerti,j, Jin-Peng Sung, Michel Bouviere, Georgios Skiniotisc,d, and Robert J. Lefkowitza<\/p>\n\n\n\n<p>2562\u20132567 | PNAS | March 7, 2017 | vol. 114 | no. 10&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.wulnalpaoycm_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.wulnalpaoycm\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.wulnalpaoycm\"><\/a>2022-09-28<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u535a\u58eb\u8ab2\u7a0b\u5358\u4f4d\u53d6\u5f97\u8005\u306e\u5742\u7530\u65e9\u82d7\u3067\u3059\u3002<\/p>\n\n\n\n<p>9\u670828\u65e5(\u6c34)\u306e Neuroclub\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124722007586\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S2211124722007586<\/a><\/p>\n\n\n\n<p>TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors<\/p>\n\n\n\n<p>Gao Y, Ma R, Weng W, Zhang H, Wang Y, Guo R, Gu X, Yang Y, Yang F, Zhou A, Cheng J, Chen ZY, Zhu MX, Li Y. TRPV1 SUMOylation suppresses itch by inhibiting TRPV1 interaction with H1 receptors. Cell Rep. 2022 Jun 14;39(11):110972. doi: 10.1016\/j.celrep.2022.110972. PMID: 35705043.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.261czf939hmm_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.261czf939hmm\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.261czf939hmm\"><\/a>2022-09-14<\/h2>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u30fb\u5fd7\u725f\u7530\uff1a<\/p>\n\n\n\n<p>\u660e\u65e5\u306f\u4e0b\u8a18URL\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/t\/vNT1sbtQrQvrfDGL\">https:\/\/www.dropbox.com\/t\/vNT1sbtQrQvrfDGL<\/a><\/p>\n\n\n\n<p>Experimenters&#8217; sex modulates mouse behaviors and neural responses to ketamine via corticotropin releasing factor<\/p>\n\n\n\n<p>Polymnia Georgiou&nbsp;<a href=\"http:\/\/et.al\/\" target=\"_blank\" rel=\"noreferrer noopener\">et.al<\/a>.<\/p>\n\n\n\n<p>Nat Neurosci. 2022 Sep;25(9):1191-1200. doi: 10.1038\/s41593-022-01146-x. Epub 2022 Aug 30.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.h6s3n6fbaimx_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.h6s3n6fbaimx\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.h6s3n6fbaimx\"><\/a>2022-09-07<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\uff1a\u6749\u6751\u5f25\u6075<\/p>\n\n\n\n<p>Medullary kappa-opioid receptor neurons inhibit pain and itch through a descending circuit. Nguyen E, Smith KM, Cramer N, Holland RA, Bleimeister IH, Flores-Felix K,&nbsp; Silberberg H, Keller A, Le Pichon CE, Ross SE. Brain. 2022 Jul 29;145(7):2586-2601. doi: 10.1093\/brain\/awac189.<\/p>\n\n\n\n<p>PMID: 35598161&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.asno71yt4ux_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.asno71yt4ux\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.asno71yt4ux\"><\/a>2022-07-27<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\uff1a\u52a0\u85e4<\/p>\n\n\n\n<p>Belin S, Maki BA, Catlin J, Rein BA, Popescu GK. Membrane Stretch Gates NMDA Receptors. J Neurosci. 2022 Jul 20;42(29):5672-5680.<\/p>\n\n\n\n<p>doi: 10.1523\/JNEUROSCI.0350-22.2022. Epub 2022 Jun 15. PMID: 35705487.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.c0ppif9ls9mn_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c0ppif9ls9mn\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c0ppif9ls9mn\"><\/a>2022-07-20<\/h2>\n\n\n\n<p>\u4f11\u4f1a<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.yvkq7lw870mo_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yvkq7lw870mo\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yvkq7lw870mo\"><\/a>2022-07-13<\/h2>\n\n\n\n<p>\u85ac\u7406\uff1a\u7c7e\u5c71\u6559\u6388<\/p>\n\n\n\n<p>&nbsp;Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release<\/p>\n\n\n\n<p>By Takuya Hikima, Paul Witkovsky, Latika Khatri, Moses V. Chao and Margaret E. Rice<\/p>\n\n\n\n<p>Journal of Neuroscience 11 May 2022, 42 (19) 3919-3930; DOI:&nbsp;<a href=\"https:\/\/doi.org\/10.1523\/JNEUROSCI.2416-21.2022\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.1523\/JNEUROSCI.2416-21.2022<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/www.jneurosci.org\/content\/42\/19\/3919\" target=\"_blank\" rel=\"noreferrer noopener\">Synaptotagmins 1 and 7 Play Complementary Roles in Somatodendritic Dopamine Release | Journal of Neuroscience (jneurosci.org)<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.tmyg92tk5501_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tmyg92tk5501\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tmyg92tk5501\"><\/a>2022-07-06<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u85ac\u7406\u5b66\u30fb\u4e2d\u6751<\/p>\n\n\n\n<p><strong>Visualizing synaptic dopamine efflux with a 2D composite nanofilm<\/strong><\/p>\n\n\n\n<p>Chandima Bulumulla, Andrew T Krasley, Ben Cristofori-Armstrong, William C Valinsky, Deepika Walpita, David Ackerman, David E Clapham, Abraham G Beyene<\/p>\n\n\n\n<p>eLife&nbsp;&nbsp;<a href=\"https:\/\/doi.org\/10.7554\/eLife.78773\" target=\"_blank\" rel=\"noreferrer noopener\">https:\/\/doi.org\/10.7554\/eLife.78773<\/a><\/p>\n\n\n\n<p>\u8ad6\u6587\u306f\u4ee5\u4e0b\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/elifesciences.org\/download\/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvNzg3NzMvZWxpZmUtNzg3NzMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzc4Nzcz\/elife-78773-v1.pdf?_hash=47HFPYB3xrPmMLs5HoSd84R3ejKOV%2Boj7nqzjfc9%2F08%3D\">https:\/\/elifesciences.org\/download\/aHR0cHM6Ly9jZG4uZWxpZmVzY2llbmNlcy5vcmcvYXJ0aWNsZXMvNzg3NzMvZWxpZmUtNzg3NzMtdjEucGRmP2Nhbm9uaWNhbFVyaT1odHRwczovL2VsaWZlc2NpZW5jZXMub3JnL2FydGljbGVzLzc4Nzcz\/elife-78773-v1.pdf?_hash=47HFPYB3xrPmMLs5HoSd84R3ejKOV%2Boj7nqzjfc9%2F08%3D<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.c74lhz1av9i9_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c74lhz1av9i9\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c74lhz1av9i9\"><\/a>2022-06-29<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u30fb\u9ad8\u6a4b<\/p>\n\n\n\n<p>Neuroimmune cardiovascular interfaces control atherosclerosis.<\/p>\n\n\n\n<p>Mohanta SK, Peng L, Li Y, Lu S, Sun T, Carnevale L, Perrotta M, Ma Z, F\u00f6rstera B, Stanic K, Zhang C, Zhang X, Szczepaniak P, Bianchini M, Saeed BR, Carnevale R, Hu D, Nosalski R, Pallante F, Beer M, Santovito D, Ert\u00fcrk A, Mettenleiter TC, Klupp BG, Megens RTA, Steffens S, Pelisek J, Eckstein HH, Kleemann R, Habenicht L, Mallat Z, Michel JB, Bernhagen J, Dichgans M, D&#8217;Agostino G, Guzik TJ, Olofsson PS, Yin C, Weber C, Lembo G, Carnevale D, Habenicht AJR.<\/p>\n\n\n\n<p>Nature. 2022 May;605(7908):152-159.<\/p>\n\n\n\n<p>doi: 10.1038\/s41586-022-04673-6.&nbsp;<\/p>\n\n\n\n<p>Epub 2022 Apr 27. PMID: 35477759.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.lgl76oe8m3f5_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lgl76oe8m3f5\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lgl76oe8m3f5\"><\/a>2022-06-22<\/h2>\n\n\n\n<p>6\u670822\u65e5\u62c5\u5f53\u306e\u91ce\u53e3\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304f\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n\n\n\n<p>Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity. Karagiannis A, Gallopin T, Lacroix A, Plaisier F, Piquet J, Geoffroy H, Hepp R, Naud\u00e9 J, Le Gac B, Egger R, Lambolez B, Li D, Rossier J, Staiger JF, Imamura H, Seino S, Roeper J, Cauli B. Elife. 2021 Nov 12;10:e71424. doi: 10.7554\/eLife.71424.PMID: 34766906<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306eURL\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u7b49\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/elifesciences.org\/articles\/71424\">https:\/\/elifesciences.org\/articles\/71424<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.9og2cdhewyv0_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.9og2cdhewyv0\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.9og2cdhewyv0\"><\/a>2022-06-15<\/h2>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u3002<\/p>\n\n\n\n<p>6\u670815\u65e5\u306eNC\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<p>Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.<\/p>\n\n\n\n<p>Lopez et al, 2022<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/s\/1bvyqhppdcyqdze\/JC220615Suzuki.pdf?dl=0\">https:\/\/www.dropbox.com\/s\/1bvyqhppdcyqdze\/JC220615Suzuki.pdf?dl=0<\/a><\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>A single sub-anesthetic dose of ketamine produces a rapid and sustained<\/p>\n\n\n\n<p>antidepressant response, yet the molecular mechanisms responsible for<\/p>\n\n\n\n<p>this remain unclear. Here, we identified cell-type-specific<\/p>\n\n\n\n<p>transcriptional signatures associated with a sustained ketamine response<\/p>\n\n\n\n<p>in mice. Most interestingly, we identified the Kcnq2 gene as an<\/p>\n\n\n\n<p>important downstream regulator of ketamine action in glutamatergic<\/p>\n\n\n\n<p>neurons of the ventral hippocampus. We validated these findings through<\/p>\n\n\n\n<p>a series of complementary molecular, electrophysiological, cellular,<\/p>\n\n\n\n<p>pharmacological, behavioral, and functional experiments. We demonstrated<\/p>\n\n\n\n<p>that adjunctive treatment with retigabine, a KCNQ activator, augments<\/p>\n\n\n\n<p>ketamine&#8217;s antidepressant-like effects in mice. Intriguingly, these<\/p>\n\n\n\n<p>effects are ketamine specific, as they do not modulate a response to<\/p>\n\n\n\n<p>classical antidepressants, such as escitalopram. These findings<\/p>\n\n\n\n<p>significantly advance our understanding of the mechanisms underlying the<\/p>\n\n\n\n<p>sustained antidepressant effects of ketamine, with important clinical implications.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.cu4we8p0o1ip_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.cu4we8p0o1ip\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.cu4we8p0o1ip\"><\/a>2022-06-08<\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u306e\u5c71\u672c\u7d14\u5049\u3067\u3059\u3002<\/p>\n\n\n\n<p>6\u67088\u65e5\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.jneurosci.org\/content\/42\/10\/1930.long\" target=\"_blank\" rel=\"noreferrer noopener\">A Female-Specific Role for Calcitonin Gene-Related Peptide (CGRP) in Rodent Pain Models | Journal of Neuroscience (jneurosci.org)<\/a><\/p>\n\n\n\n<p>Paige C, Plasencia-Fernandez I, Kume M, Papalampropoulou-Tsiridou M, Lorenzo LE, David ET, He L, Mejia GL, Driskill C, Ferrini F, Feldhaus AL, Garcia-Martinez LF, Akopian AN, De Koninck Y, Dussor G, Price TJ.<\/p>\n\n\n\n<p>J Neurosci. 2022 Mar 9;42(10):1930-1944. doi: 10.1523\/JNEUROSCI.1137-21.2022. Epub 2022 Jan 20.<\/p>\n\n\n\n<p>PMID: 35058371<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.sixn41m9e5tp_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.sixn41m9e5tp\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.sixn41m9e5tp\"><\/a>2022-06-01<\/h2>\n\n\n\n<p>\u7523\u7dcf\u7814\u3000\u91e3\u6728\u6fa4\u3000\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.746214\/full\">https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.746214\/full<\/a><\/p>\n\n\n\n<p>Microstructural Tissue Changes in a Rat Model of Mild Traumatic Brain Injury<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.5c58jppp2g2e_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5c58jppp2g2e\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5c58jppp2g2e\"><\/a>2022-05-25<\/h2>\n\n\n\n<p>5\u670825\u65e5\u62c5\u5f53\u306e\u57fa\u76e4\u7814\u7a76\u65bd\u8a2d\u306e\u5c71\u6fa4\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Visualizing the native cellular organization by coupling cryofixation with expansion microscopy (Cryo-ExM), Marine H Laporte, Nikolai Klena, Virginie Hamel, Paul Guichard.&nbsp;<\/p>\n\n\n\n<p>PMID: 35027766 PMCID: PMC8828483 DOI: 10.1038\/s41592-021-01356-4.&nbsp;<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p>Cryofixation has proven to be the gold standard for efficient preservation of native cell ultrastructure compared to chemical fixation, but this approach is not widely used in fluorescence microscopy owing to implementation challenges. Here, we develop Cryo-ExM, a method that preserves native cellular organization by coupling cryofixation with expansion microscopy. This method bypasses artifacts associated with chemical fixation and its simplicity will contribute to its widespread use in super-resolution microscopy.<\/p>\n\n\n\n<p>\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u5b9c\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35027766\">https:\/\/pubmed.ncbi.nlm.nih.gov\/35027766<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.o7px79vl0ez6_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.o7px79vl0ez6\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.o7px79vl0ez6\"><\/a>2022-05-18<\/h2>\n\n\n\n<p>5\u670818\u65e5\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Cordycepin suppresses glutamatergic and GABAergic synaptic transmission through activation of A 1 adenosine receptor in rat hippocampal CA1<\/p>\n\n\n\n<p>pyramidal neurons. Jinxiu Wang, Yanchun Gong, Haoyuan Tan, Wenxi Li, Baiyi Yan, Chunfang Cheng, Juan Wan, Wei Sun, Chunhua Yuan, Li-Hua Yao<\/p>\n\n\n\n<p>PMID: 34808556 DOI: 10.1016\/j.biopha.2021.112446.<\/p>\n\n\n\n<p><strong>Abstract<\/strong><\/p>\n\n\n\n<p>Cordycepin (known as 3-deoxyadenosine, CRD), a natural product from the valuable traditional Chinese medicine Cordyceps militaris, has been reported to improve cognitive function and modulate neuroprotective effects on the central nervous system (CNS). However, the modulating mechanisms of cordycepin on information processing in hippocampal CA1 pyramidal neurons are not fully understood. To clarify how cordycepin modulates synaptic responses of pyramidal neurons in rat hippocampal CA1 region, we conducted an electrophysiological experiment using whole-cell patch-clamp technique. The spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs, respectively) and the spontaneous and miniature inhibitory postsynaptic currents (sIPSCs and mIPSCs, respectively) recorded by this technique evaluated pure single or multi-synapse responses and enabled us to accurately quantify how cordycepin influenced the pre and postsynaptic aspects of synaptic transmission. The present results showed that cordycepin significantly decreased the frequency of both glutamatergic and GABAergic postsynaptic currents without affecting the amplitude, while these inhibitory effects were antagonized by the A1 adenosine receptor antagonist (DPCPX), but not the A2A (ZM 241385), A2B (MRS1754) and A3 (MRS1191) adenosine receptor antagonists. Taken together, our results suggested that cordycepin had a clear presynaptic effect on glutamatergic and GABAergic transmission, and provided novel evidence that cordycepin suppresses the synaptic transmission through the activation of A1AR.<\/p>\n\n\n\n<p>\u4f55\u5352\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u3000\u5ddd\u6751\u5c06\u4ec1&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.pawm8vr8j3qt_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pawm8vr8j3qt\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pawm8vr8j3qt\"><\/a>2022-05-11<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u7fbd\u7530\u514b\u5f66<\/p>\n\n\n\n<p>1. Numerical Simulation: Fluctuation in Background Synaptic Activity Regulates Synaptic Plasticity<\/p>\n\n\n\n<p>Yuto Takeda, Katsuhiko Hata, Tokio Yamazaki, Masaki Kaneko, Osamu Yokoi, Chengta Tsai, Kazuo Umemura, Tetsuro Nikuni, Front Syst Neurosci. 2021 Nov 22;15:771661. PMID: 34880734 PMCID: PMC8646040 DOI: 10.3389\/fnsys.2021.771661<\/p>\n\n\n\n<p>2. Multicoding in neural information transfer suggested by mathematical analysis of the frequency-dependent synaptic plasticity in vivo<\/p>\n\n\n\n<p>Katsuhiko Hata, Osamu Araki, Osamu Yokoi, Tatsumi Kusakabe, Yoshio Yamamoto, Susumu Ito &amp; Tetsuro Nikuni, Sci Rep. 2020 Aug 18;10(1):13974. PMID: 32811844 PMCID: PMC7435278 DOI: 10.1038\/s41598-020-70876-4&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.nw898acl9bfc_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.nw898acl9bfc\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.nw898acl9bfc\"><\/a>2022-04-27<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u77f3\u5ddd\u592a\u90ce\uff08\u85ac\u7406\uff09<\/p>\n\n\n\n<p>\u660e\u65e5\u306eNeuroClub\u3067\u306f\u6dfb\u4ed8\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u57fa\u5e95\u6838\u7cfb\u306e\u904b\u52d5\u5236\u5fa1\u306e\u672c\u8cea\u306b\u8feb\u308b\u8ad6\u6587\u3067\u3059\u304c\u3001Zeta inhibitory peptide (ZIP)\u3068\u3044\u3046\u30b7\u30ca\u30d7\u30b9\u53ef\u5851\u6027\u3092\u6d88\u53bb\u3057\u3066\u3057\u307e\u3046\u30c4\u30fc\u30eb\u3092\u4f7f\u3063\u3066\u3044\u308b\u3068\u3053\u308d\u3082\u65b9\u6cd5\u8ad6\u3068\u3057\u3066\u4e00\u3064\u306e\u6ce8\u76ee\u70b9\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Wolff SBE, Ko R, \u00d6lveczky BP.<\/p>\n\n\n\n<p>Distinct roles for motor cortical and thalamic inputs to striatum during motor skill learning and execution. Sci Adv. 2022 Feb 25;8(8):eabk0231. doi: 10.1126\/sciadv.abk0231.<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>The acquisition and execution of motor skills are mediated by a distributed motor network, spanning cortical and subcortical brain areas. The sensorimotor striatum is an important cog in this network, yet the roles of its two main inputs, from motor cortex and thalamus, remain largely unknown. To address this, we silenced the inputs in rats trained on a task that results in highly stereotyped and idiosyncratic movement patterns. While striatal-projecting motor cortex neurons were critical for learning these skills, silencing this pathway after learning had no effect on performance. In contrast, silencing striatal-projecting thalamus neurons disrupted the execution of the learned skills, causing rats to revert to species-typical pressing behaviors and preventing them from relearning the task. These results show distinct roles for motor cortex and thalamus in the learning and execution of motor skills and suggest that their interaction in the striatum underlies experience-dependent changes in subcortical motor circuits.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.qaj12nfjbmpa_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qaj12nfjbmpa\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.qaj12nfjbmpa\"><\/a>2022-04-20<\/h2>\n\n\n\n<p>4\u670820\u65e5\u306eWednesday Morning Journal Club\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u9ad8\u6a4b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u306f\u3001<\/p>\n\n\n\n<p>Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC\/ERK\/CREB pathway in an experimental chronic migraine rat model.<\/p>\n\n\n\n<p>Tian R, Zhang Y, Pan Q, Wang Y, Wen Q, Fan X, Qin G, Zhang D, Chen L, Zhang Y, Zhou J.<\/p>\n\n\n\n<p>J Headache Pain. 2022 Mar 8;23(1):35.<\/p>\n\n\n\n<p>doi: 10.1186\/s10194-022-01403-1. PMID: 35260079; PMCID: PMC8903578.<\/p>\n\n\n\n<p>\u8ad6\u6587\u306f\u4e0b\u8a18URL\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8903578\">https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8903578<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.xtxz0bmgkfhl_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xtxz0bmgkfhl\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xtxz0bmgkfhl\"><\/a><strong>2022-04-13<\/strong><\/h2>\n\n\n\n<p>\u4eca\u9031\u306eNeuroclub\u306e\u62c5\u5f53\u306f\u4e45\u4fdd\u3067\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3059\u308b\u4e88\u5b9a\u3067\u3059\u3002<\/p>\n\n\n\n<p>Individual human cortical progenitors can produce excitatory and inhibitory neurons<\/p>\n\n\n\n<p>Nature<\/p>\n\n\n\n<p>2022 Jan;601(7893):397-403.&nbsp;doi: 10.1038\/s41586-021-04230-7.&nbsp;Epub 2021 Dec 15.<\/p>\n\n\n\n<p>\u3000\u5148\u3005\u9031\u3001\u5409\u6c38\u541b\u304c\u7d39\u4ecb\u3057\u3066\u304f\u308c\u305f\u8ad6\u6587\u306b\u95a2\u9023\u3057\u305f\u8ad6\u6587\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3000\u30a4\u30f3\u30c8\u30e9\u3067\u4ee5\u4e0b\u306e\u30ea\u30f3\u30af\u304b\u3089\u5165\u624b\u53ef\u80fd\u304b\u3068\u5b58\u3058\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-021-04230-7\">https:\/\/www.nature.com\/articles\/s41586-021-04230-7<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.xvgyzhci4k64_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xvgyzhci4k64\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xvgyzhci4k64\"><\/a><strong>2022<\/strong><strong>-04-06<\/strong><\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\u751f\u306e\u4f50\u85e4\u5948\u4fdd\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>4\u67086\u65e5\u306e Neuroclub\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/s\/a4yyfewuf76akd4\/Pain_modulates_dopamine_neurons_via_a_spinal-parab.pdf?dl=0\">https:\/\/www.dropbox.com\/s\/a4yyfewuf76akd4\/Pain_modulates_dopamine_neurons_via_a_spinal-parab.pdf?dl=0<\/a><\/p>\n\n\n\n<p>Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.<\/p>\n\n\n\n<p>Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S.<\/p>\n\n\n\n<p>Nat Neurosci. 2021 Oct;24(10):1402-1413. doi: 10.1038\/s41593-021-00903-8. Epub 2021 Aug 9.<\/p>\n\n\n\n<p>PMID: 34373644<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.afztkxdvo1g1_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.afztkxdvo1g1\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.afztkxdvo1g1\"><\/a><strong>2022-03-30<\/strong><\/h2>\n\n\n\n<p>\u4eca\u9031\u306eNeuroclub\u306f\u89e3\u5256\u5b66\u306e\u5409\u6c38\u306e\u62c5\u5f53\u3067\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>The human cortex contains inhibitory interneurons derived from the medial ganglionic eminence (MGE), a germinal zone in the embryonic ventral forebrain. How this germinal zone generates sufficient interneurons for the human brain remains unclear. We found that the human MGE (hMGE) contains nests of proliferative neuroblasts with ultrastructural and transcriptomic features that distinguish them from other progenitors in the hMGE. When dissociated hMGE cells are transplanted into the neonatal mouse brain, they reform into nests containing proliferating neuroblasts that generate young neurons that migrate extensively into the mouse forebrain and mature into different subtypes of functional interneurons. Together, these results indicate that the nest organization and sustained proliferation of neuroblasts in the hMGE provide a mechanism for the extended production of interneurons for the human forebrain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.8pvaeteaxbtl_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.8pvaeteaxbtl\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.8pvaeteaxbtl\"><\/a><strong>2022-03-23<\/strong><\/h2>\n\n\n\n<p>\u62c5\u5f53:\u4e0a\u5712\u4fdd\u4ec1\u6559\u6388\uff08\u75bc\u75db\u5236\u5fa1\u7814\u7a76\u8b1b\u5ea7\u30fb\u75db\u307f\u8133\u79d1\u5b66\u30bb\u30f3\u30bf\u30fc \u652f\u6301\u7642\u6cd5\u75bc\u75db\u5236\u5fa1\u7814\u7a76\u5ba4\uff09<\/p>\n\n\n\n<p>\u5275\u85ac\u306b\u95a2\u3059\u308b\u69d8\u3005\u306a\u652f\u63f4\u7d44\u7e54\u306b\u3064\u3044\u3066\u7d39\u4ecb&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.kh9eb24n5lv5_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kh9eb24n5lv5\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.kh9eb24n5lv5\"><\/a><strong>2022-03-09<\/strong><\/h2>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u535a\u58eb\u8ab2\u7a0b\u5358\u4f4d\u53d6\u5f97\u8005\u306e\u5742\u7530\u65e9\u82d7\u3067\u3059\u3002<\/p>\n\n\n\n<p>3\u67089\u65e5\u306e Neuroclub\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0896627321010151\">https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0896627321010151<\/a><\/p>\n\n\n\n<p>Glutamate in primary afferents is required for itch transmission<\/p>\n\n\n\n<p>Cui L, Guo J, Cranfill SL, Gautam M, Bhattarai J, Olson W, Beattie K, Challis RC, Wu Q, Song X, Raabe T, Gradinaru V, Ma M, Liu Q, Luo W. Glutamate in primary afferents is required for itch transmission. Neuron. 2021 Dec 30:S0896-6273(21)01015-1. doi: 10.1016\/j.neuron.2021.12.007. Epub ahead of print. PMID: 34986325.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.3ho7gvcv8pxe_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.3ho7gvcv8pxe\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.3ho7gvcv8pxe\"><\/a><strong>2022-03-02<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\u751f\u30fb\u6d6e\u5730\u91cc\u4f73\u5b50<\/p>\n\n\n\n<p>Dynamics of a disinhibitory prefrontal microcircuit in controlling<\/p>\n\n\n\n<p>social competition<\/p>\n\n\n\n<p>Chaoyi Zhang, Hong Zhu, Zheyi Ni, Qiuhong Xin, Tingting Zhou, Runlong Wu,<\/p>\n\n\n\n<p>&nbsp;Guangping Gao, Zhihua Gao, Huan Ma, Haohong Li, Miao He, Jue Zhang,<\/p>\n\n\n\n<p>Heping Cheng, Hailan Hu<\/p>\n\n\n\n<p>Neuron. 2022 Feb 2;110(3):516-531.e6. doi: 10.1016\/j.neuron.2021.10.034.<\/p>\n\n\n\n<p>Epub 2021 Nov 17.<\/p>\n\n\n\n<p>PMID: 34793692 DOI: 10.1016\/j.neuron.2021.10.034&nbsp;<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.azcxny3yc3e3_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.azcxny3yc3e3\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.azcxny3yc3e3\"><\/a><strong>2022-02-02<\/strong><\/h1>\n\n\n\n<p>Brainstem Mechanisms of Pain Modulation: A within-Subjects 7T fMRI Study of Placebo Analgesic and Nocebo Hyperalgesic Responses.<\/p>\n\n\n\n<p>Crawford LS, Mills EP, Hanson T, Macey PM, Glarin R, Macefield VG, Keay KA, Henderson LA.<\/p>\n\n\n\n<p>J Neurosci. 2021 Nov 24;41(47):9794-9806.<\/p>\n\n\n\n<p>doi: 10.1523\/JNEUROSCI.0806-21.2021. Epub 2021 Oct 25. PMID: 34697093; PMCID: PMC8612641.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.mk6hedoavgad_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mk6hedoavgad\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mk6hedoavgad\"><\/a><strong>2022-01-26<\/strong><\/h1>\n\n\n\n<p>26\u65e5\uff08\u6c34\uff09\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u304a\u624b\u6570\u3067\u3059\u304c\u3001\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u5404\u81ea\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u7c7e\u5c71\u4fca\u5f66<\/p>\n\n\n\n<p>Loss of nigral excitation of cholinergic interneurons contributes to parkinsonian motor impairments<\/p>\n\n\n\n<p>Yuan Cai , Beatriz E Nielsen, Emma E Boxer, Jason Aoto &amp; Christopher P Ford<\/p>\n\n\n\n<p>Neuron 109, 1137-1149, 2021<\/p>\n\n\n\n<p>&nbsp;<strong>2022-01-19<\/strong><\/p>\n\n\n\n<p>\u52a0\u85e4\u7dcf\u592b<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\uff0e<\/p>\n\n\n\n<p>Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson&#8217;s disease.<\/p>\n\n\n\n<p>Roostalu U, Salinas CBG, Thorbek DD, Skytte JL, Fabricius K, Barkholt P, John LM, Jurtz VI, Knudsen LB, Jelsing J, Vrang N, Hansen HH, Hecksher-S\u00f8rensen J.<\/p>\n\n\n\n<p>Dis Model Mech. 2019 Nov 22;12(11):dmm042200.<\/p>\n\n\n\n<p>doi: 10.1242\/dmm.042200.<\/p>\n\n\n\n<p>PMID: 31704726;<\/p>\n\n\n\n<p>PMCID: PMC6899010.<\/p>\n\n\n\n<p>&nbsp;<strong>2022-01-12<\/strong><\/p>\n\n\n\n<p>\u4e2d\u6751\u884c\u5b8f<\/p>\n\n\n\n<p>Ucar et al. Nature volume 600, pages686\u2013689 (2021)<\/p>\n\n\n\n<p>Mechanical actions of dendritic-spine enlargement on presynaptic<\/p>\n\n\n\n<p>exocytosis<\/p>\n\n\n\n<p>&nbsp;<strong>2022-01-05<\/strong><\/p>\n\n\n\n<p>1\/5 NeuroClub\u62c5\u5f53\u306e\u91ce\u53e3\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8&nbsp;\u8a2a\u554f\u7814\u7a76\u54e1\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5f53\u65e5\u306f\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304f\u4e88\u5b9a\u3067\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>**\u8ad6\u6587\u306f\u4e0b\u8a18URL\u3088\u308a\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u53ef\u80fd\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u2193<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41386-021-01196-y\">https:\/\/www.nature.com\/articles\/s41386-021-01196-y<\/a><\/p>\n\n\n\n<p>Optogenetic stimulation of lateral hypothalamic orexin\/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours.<\/p>\n\n\n\n<p>Thomas CS, Mohammadkhani A, Rana M, Qiao M, Baimel C, Borgland SL.<\/p>\n\n\n\n<p>Neuropsychopharmacology. 2021 Oct 18. doi: 10.1038\/s41386-021-01196-y. Online ahead of print.<\/p>\n\n\n\n<p>PMID: 34663867<\/p>\n\n\n\n<p>&nbsp;<strong>2021-12-22<\/strong><\/p>\n\n\n\n<p>\u5206\u5b50\u751f\u7406\u5b66\u306e\u5c71\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>12\u670822\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18URL\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u307e\u3059\u3088\u3046\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3069\u3046\u305e\u5b9c\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>&nbsp;\u5c71\u6fa4\u5fb7\u5fd7\u5b50(toshiko1998@jikei.ac.jp)<\/p>\n\n\n\n<p>\u5206\u5b50\u751f\u7406\u5b66\u8b1b\u5ea7\uff08\u5185\u7dda&nbsp;2216)<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-021-04001-4\">https:\/\/www.nature.com\/articles\/s41586-021-04001-4<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34646018\">https:\/\/pubmed.ncbi.nlm.nih.gov\/34646018<\/a><\/p>\n\n\n\n<p>Nature . 2021 Oct;598(7882):641-645.<\/p>\n\n\n\n<p>A neuroanatomical basis for electroacupuncture to drive the vagal-adrenal axis<\/p>\n\n\n\n<p>Shenbin Liu #&nbsp; 1 &nbsp; 2 &nbsp; 3 &nbsp; 4 , Zhifu Wang #&nbsp; 1 , Yangshuai Su&nbsp; 1 &nbsp; 5 , Lu Qi&nbsp; 1 , Wei Yang&nbsp; 1 , Mingzhou Fu&nbsp; 1 , Xianghong Jing&nbsp; 5 , Yanqing Wang&nbsp; 2 &nbsp; 3 &nbsp; 4 , Qiufu Ma&nbsp; 6<\/p>\n\n\n\n<p>&nbsp;<strong>2021-12-15<\/strong><\/p>\n\n\n\n<p>\u7523\u7dcf\u7814\uff06\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u91e3\u6728\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>12\u670815\u65e5\u306eNC\u3067\u306f\u8ff7\u3063\u305f\u3093\u3067\u3059\u304cMRI\u306e\u666e\u53ca\u3082\u76ee\u7684\u3068\u3057\u3066\u6700\u8fd1\u767a\u8868\u3057\u305f\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>PDF\u306f\u4e0b\u8a18\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S1053811921006881?token=CDABC242C1C893E2C229404699735F15BF839EBF08E8A7CF9840AE34DF205EC19FE21F0A9669FA3B4534CFB3CB84A9CE&amp;originRegion=us-east-1&amp;originCreation=20211212133137\">https:\/\/reader.elsevier.com\/reader\/sd\/pii\/S1053811921006881?token=CDABC242C1C893E2C229404699735F15BF839EBF08E8A7CF9840AE34DF205EC19FE21F0A9669FA3B4534CFB3CB84A9CE&amp;originRegion=us-east-1&amp;originCreation=20211212133137<\/a><\/p>\n\n\n\n<p>Impact of anesthesia on static and dynamic functional connectivity in mice<\/p>\n\n\n\n<p>Tsurugizawa T, Yoshimaru D,<\/p>\n\n\n\n<p>Neuroimage, 2021 Nov 1;241:118413. doi: 10.1016\/j.neuroimage.2021.118413<\/p>\n\n\n\n<p>&nbsp;<strong>2021-12-01<\/strong><\/p>\n\n\n\n<p>12\u67081\u65e5\u306eNC\u3067\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>PDF\u306f\u4e0b\u8a18URL\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3057\u3066\u304f\u3060\u3055\u3044\u307e\u3059\u3088\u3046\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A forebrain neural substrate for behavioral thermoregulation.<\/p>\n\n\n\n<p>Jung S, Lee M, Kim DY, Son C, Ahn BH, Heo G, Park J, Kim M, Park HE, Koo<\/p>\n\n\n\n<p>DJ, Park JH, Lee JW, Choe HK, Kim SY.<\/p>\n\n\n\n<p>Neuron. 2021 Oct 20:S0896-6273(21)00712-1. doi: 10.1016\/j.neuron.2021.09.<\/p>\n\n\n\n<p>039. Online ahead of print.<\/p>\n\n\n\n<p>PMID: 34687664<\/p>\n\n\n\n<p>&#8212;<\/p>\n\n\n\n<p>Yae K. Sugimura<\/p>\n\n\n\n<p>Research Associate, PhD<\/p>\n\n\n\n<p>Department of Neuroscience,<\/p>\n\n\n\n<p>Center for Neuroscience of Pain,<\/p>\n\n\n\n<p>Jikei University School of Medicine<\/p>\n\n\n\n<p>&nbsp;<strong>2021-11-24<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u9234\u6728\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>PDF\u306f\u4e0b\u8a18URL\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/s\/c46vuhm2bl9m70g\/JC211124Suzuki.pdf?dl=0\">https:\/\/www.dropbox.com\/s\/c46vuhm2bl9m70g\/JC211124Suzuki.pdf?dl=0<\/a><\/p>\n\n\n\n<p>Molecular and functional architecture of striatal dopamine release sites<\/p>\n\n\n\n<p>Banerjee et al., 2022 Neuron<\/p>\n\n\n\n<p><strong>2021-11-17<\/strong><\/p>\n\n\n\n<p>11\u670817\u65e5\u62c5\u5f53\u306e\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/jnc.15496\">https:\/\/onlinelibrary.wiley.com\/doi\/full\/10.1111\/jnc.15496<\/a><\/p>\n\n\n\n<p>Spontaneous, transient adenosine release is not enhanced in<\/p>\n\n\n\n<p>the CA1 region of hippocampus during severe ischemia models<\/p>\n\n\n\n<p>Mallikarjunarao Ganesana, B. Jill Venton<\/p>\n\n\n\n<p><strong>2021-11-10<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u5fb3\u6c38\u4eae\u592aPD<\/p>\n\n\n\n<p>Capillary-associated microglia regulate vascular structure and function through PANX1-P2RY12 coupling in mice<\/p>\n\n\n\n<p>Bisht K, Okojie KA, Sharma K, Lentferink DH, Sun YY, Chen HR, Uweru JO, Amancherla S, Calcuttawala Z, Campos-Salazar AB, Corliss B, Jabbour L, Benderoth J, Friestad B, Mills WA 3rd, Isakson BE, Tremblay M\u00c8, Kuan CY, Eyo UB.<\/p>\n\n\n\n<p>Nat Commun. 2021 Sep 6;12(1):5289. doi: 10.1038\/s41467-021-25590-8. PMID: 34489419; PMCID: PMC8421455.<\/p>\n\n\n\n<p><strong>2021-10-27<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u77f3\u5ddd\u592a\u90ce\u51c6\u6559\u6388<\/p>\n\n\n\n<p>A Purkinje cell to parabrachial nucleus pathway enables broad cerebellar influence over the forebrain and emotional valence.<\/p>\n\n\n\n<p>Christopher H. Chen, Leannah N. Newman, Amanda P. Stark, Katherine E. Bond, Dawei Zhang, Kefiloe Mutume, Isabella Flaquer, Wade G. Regehr*<\/p>\n\n\n\n<p><strong>2021-10-20<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u4f50\u85e4\u5948\u4fdd\u5b50\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u96622\u5e74\uff09<\/p>\n\n\n\n<p>\u7d39\u4ecb\u8ad6\u6587\uff1aNeuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex. Wang YQ, Wang J, Xia SH, Gutstein HB, Huang YH, Schl\u00fcter OM, Cao JL, Dong Y. Pain. 2021 May 1;162(5):1322-1333. doi: 10.1097\/j.pain.0000000000002149.<\/p>\n\n\n\n<p>PMID: 33230002.<\/p>\n\n\n\n<p><strong>2021-10-13<\/strong><\/p>\n\n\n\n<p>\u9ebb\u9154\u79d1\u5b66\u8b1b\u5ea7\u30da\u30a4\u30f3\u30af\u30ea\u30cb\u30c3\u30af<\/p>\n\n\n\n<p>\u5009\u7530\u4e8c\u90ce\u6559\u6388\u7279\u5225\u30bb\u30df\u30ca\u30fc<\/p>\n\n\n\n<p><strong>2021-10-06<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u533b\u5b66\u79d12\u5e74\u30fb\u5185\u85e4\u793c<\/p>\n\n\n\n<p>Ferguson BR, Gao WJ.<\/p>\n\n\n\n<p>Thalamic Control of Cognition and Social Behavior Via Regulation of Gamma-Aminobutyric Acidergic Signaling and Excitation\/Inhibition Balance in the Medial Prefrontal Cortex.<\/p>\n\n\n\n<p>Biol Psychiatry. 2018 Apr 15;83(8):657-669.<\/p>\n\n\n\n<p>doi: 10.1016\/j.biopsych.2017.11.033.<\/p>\n\n\n\n<p>Epub 2017 Dec 7.<\/p>\n\n\n\n<p>PMID: 29373121;<\/p>\n\n\n\n<p>PMCID: PMC5862785.<\/p>\n\n\n\n<p><strong>2021.09.29<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\u751f4\u5e74\u30fb\u5e03\u9593\u5bdb\u7ae0<\/p>\n\n\n\n<p>Oxytocin in the anterior cingulate cortex attenuates neuropathic pain and emotional anxiety by inhibiting presynaptic long-term potentiation.<\/p>\n\n\n\n<p>Xu-Hui Li, Takanori Matsuura, Man Xue, Qi-Yu Chen, Ren-Hao Liu, Jing-Shan Lu, Wantong Shi, Kexin Fan, Zhaoxiang Zhou, Zhuang Miao, Jiale Yang,<\/p>\n\n\n\n<p>&nbsp;Sara Wei, Feng Wei, Tao Chen, Min Zhuo<\/p>\n\n\n\n<p>PMID: 34289348 DOI: 10.1016\/j.celrep.2021.109411.<\/p>\n\n\n\n<p><strong>2021-09-22<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u4e5d\u5dde\u5927\u5b66\u5927\u5b66\u9662\u4fee\u58eb\uff11\u5e74\u3000\u5185\u5c71\u7473\u548c\u5b50<\/p>\n\n\n\n<p>HepaCAM controls astrocyte self-organization and coupling<\/p>\n\n\n\n<p>Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, R\u00fclicke T, Hippenmeyer S, Est\u00e9vez R, Ji RR, Eroglu C.<\/p>\n\n\n\n<p>Neuron. 2021 Aug 4;109(15):2427-2442.e10. doi: 10.1016\/j.neuron.2021.05.025. Epub 2021 Jun 24. PMID: 34171291.&nbsp;<\/p>\n\n\n\n<p><strong>2021-09-15<\/strong><\/p>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u8a2a\u554f\u7814\u7a76\u54e1\u30fb\u5c71\u672c\u7d14\u5049<\/p>\n\n\n\n<p>Region-Specific and State-Dependent Astrocyte Ca 2+ Dynamics during the Sleep-Wake Cycle in Mice, Tsunematsu T, Sakata S, Sanagi T, Tanaka KF, Matsui K. J Neurosci. 2021 Jun 23;41(25):5440-5452. doi: 10.1523\/JNEUROSCI.2912-20.2021. Epub 2021 May 18.<\/p>\n\n\n\n<p>PMID: 34006590<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.vlj131589sb5_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.vlj131589sb5\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.vlj131589sb5\"><\/a><strong>2021-09-07<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u89e3\u5256\u5b66\uff1a\u5409\u6c38\u601c\u53f2<\/p>\n\n\n\n<p>iScience. 2021 Mar 6;24(4):102277.<\/p>\n\n\n\n<p>doi: 10.1016\/j.isci.2021.102277. eCollection 2021 Apr 23.<\/p>\n\n\n\n<p>Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling<\/p>\n\n\n\n<p>Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-Ichiro Kubo, Kazunori Nakajima<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.tk6lbrc8n632_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tk6lbrc8n632\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tk6lbrc8n632\"><\/a><strong>2021\u5e749\u67081\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u30fb\u9ad8\u6a4b\u7531\u9999\u91cc<\/p>\n\n\n\n<p>Pain modulates dopamine neurons via a spinal-parabrachial-mesencephalic circuit.<\/p>\n\n\n\n<p>Yang H, de Jong JW, Cerniauskas I, Peck JR, Lim BK, Gong H, Fields HL, Lammel S.<\/p>\n\n\n\n<p>Nat Neurosci. 2021 Aug 9.<\/p>\n\n\n\n<p>doi: 10.1038\/s41593-021-00903-8.<\/p>\n\n\n\n<p>Epub ahead of print.<\/p>\n\n\n\n<p>PMID: 34373644.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.rlww1a84g1hd_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.rlww1a84g1hd\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.rlww1a84g1hd\"><\/a><strong>2021\u5e747\u670814\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff08\u30d4\u30f3\u30c1\u30d2\u30c3\u30bf\u30fc\uff09\uff1a\u52a0\u85e4\uff08\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\uff09<\/p>\n\n\n\n<p>Ho J, Tumkaya T, Aryal S, Choi H, Claridge-Chang A. Moving beyond P values: data analysis with estimation graphics. Nat Methods. 2019 Jul;16(7):565-566. doi: 10.1038\/s41592-019-0470-3. PMID: 31217592.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.xqm2cqmnyij4_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xqm2cqmnyij4\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.xqm2cqmnyij4\"><\/a><strong>2021\u5e747\u67087\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u77f3\u5ddd\u592a\u90ce\u5148\u751f\uff08\u85ac\u7406\uff09<\/p>\n\n\n\n<p>Optogenetic stimulation of medial amygdala GABA neurons with kinetically different channelrhodopsin variants yield opposite behavioral outcomes<\/p>\n\n\n\n<p>Aiste Baleisyte, Ralf Schneggenburger, Olexiy Kochubey<\/p>\n\n\n\n<p>\u7121\u6599\u3067\u3059\u306e\u3067\u3001\u4e0b\u8a18\u304b\u3089\u76f4\u63a5\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1101\/2021.06.30.450543\">https:\/\/doi.org\/10.1101\/2021.06.30.450543<\/a><\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.l2ppyb46k8wg_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l2ppyb46k8wg\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l2ppyb46k8wg\"><\/a><strong>2021\u5e746\u670830\u65e5<\/strong><\/h1>\n\n\n\n<p>\u89e3\u5256\u5b66\u8b1b\u5ea7\u306b\u8d74\u4efb\u3055\u308c\u305f\u4e45\u4fdd\u5065\u4e00\u90ce\u6559\u6388\u306e\u30bb\u30df\u30ca\u30fc\uff0e<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.tofmewloyvlf_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tofmewloyvlf\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.tofmewloyvlf\"><\/a><strong>2021\u5e746\u670823\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u85ac\u7406\u5b66\u8b1b\u5ea7\u30fb\u9234\u6728\u6c5f\u6d25\u5b50\u5148\u751f<\/p>\n\n\n\n<p>\u7d39\u4ecb\u8ad6\u6587\uff1a<\/p>\n\n\n\n<p>Efficient optogenetic silencing of neurotransmitter release with a mosquito rhodopsin. Mahn et al, Neuron 109 1621-1635, 2021.<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.m2g1bmo43q18_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m2g1bmo43q18\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m2g1bmo43q18\"><\/a><strong>2021\u5e746\u670816\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u6d6e\u5730\u91cc\u4f73\u5b50\u5927\u5b66\u9662\u751f\uff08\u7cd6\u5c3f\u75c5\u5185\u79d1\uff09<\/p>\n\n\n\n<p>\u7d39\u4ecb\u8ad6\u6587\uff1a<\/p>\n\n\n\n<p>Neuronal signals regulate obesity-induced \u03b2-cell proliferation by FoxM1<\/p>\n\n\n\n<p>dependent mechanism, Junpei Yamamoto, Junta Imai, Tomohito Izumi, Hironori Takahashi, Yohei Kawana, Kei Takahashi, Shinjiro Kodama, Keizo Kaneko, Junhong Gao, Kenji Uno, Shojiro Sawada, Tomoichiro Asano, Vladimir V Kalinichenko, Etsuo A Susaki, Makoto Kanzaki, Hiroki R Ueda, Yasushi Ishigaki, Tetsuya Yamada, Hideki Katagiri,&nbsp; Nat Commun. 2017 Dec 5;8(1):1930. doi: 10.1038\/s41467-017-01869-7. PMID: 29208957 PMCID: PMC5717276 DOI: 10.1038\/s41467-017-01869-7<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.we4i86jz0de_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.we4i86jz0de\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.we4i86jz0de\"><\/a><strong>2021\u5e746\u67089\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u7c7e\u5c71\u4fca\u5f66\u6559\u6388<\/p>\n\n\n\n<p>Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell<\/p>\n\n\n\n<p>by Kevin M. Manz, Benjamin C. Coleman, Carrie A. Grueter, Brenda C. Shields, Michael R. Tadross and Brad A. Grueter<\/p>\n\n\n\n<p>J Neurosci. 41:3752-3763, 2021<\/p>\n\n\n\n<h1 class=\"wp-block-heading\" id=\"h.yfo71xz5bvo0_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yfo71xz5bvo0\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yfo71xz5bvo0\"><\/a><strong>2021\u5e746\u67082\u65e5<\/strong><\/h1>\n\n\n\n<p>\u62c5\u5f53\uff1a\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u30fb\u6749\u6751<\/p>\n\n\n\n<p>\u7d39\u4ecb\u8ad6\u6587\uff1a<\/p>\n\n\n\n<p>Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons.<\/p>\n\n\n\n<p>Bowen AJ, Chen JY, Huang YW, Baertsch NA, Park S, Palmiter RD.<\/p>\n\n\n\n<p>eLife. 2020 Aug 28;9:e59799. doi: 10.7554\/eLife.59799. PMID: 32856589<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.pajk2e1u9uq0_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pajk2e1u9uq0\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pajk2e1u9uq0\"><\/a>\u3053\u306e\u9593\u7d04\uff12\u5e74\u306e\u8a18\u9332\u306f\u8ffd\u3063\u3066\u63b2\u793a\u3057\u307e\u3059\uff0e<\/h2>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.adrw0mn3xgpe_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.adrw0mn3xgpe\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.adrw0mn3xgpe\"><\/a>2019\u5e747\u670817\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC190717@\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD \u5c71\u6fa4<\/p>\n\n\n\n<p>\u5206\u5b50\u751f\u7406\u306e\u5c71\u6fa4\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Nakashima A, Ihara N, Shigeta M, Kiyonari H, Ikegaya Y, Takeuchi H.<\/p>\n\n\n\n<p>Structured spike series specify gene expression patterns for olfactory<\/p>\n\n\n\n<p>circuit formation. Science, 365 (6448), 2019.<\/p>\n\n\n\n<p>Neural circuits emerge through the interplay of genetic programming and<\/p>\n\n\n\n<p>activity-dependent processes. During the development of the mouse olfactory<\/p>\n\n\n\n<p>map, axons segregate into distinct glomeruli in an olfactory receptor<\/p>\n\n\n\n<p>(OR)-dependent manner. ORs generate a combinatorial code of axon-sorting<\/p>\n\n\n\n<p>molecules whose expression is regulated by neural activity. However, it<\/p>\n\n\n\n<p>remains unclear how neural activity induces OR-specific expression patterns<\/p>\n\n\n\n<p>of axon-sorting molecules. We found that the temporal patterns of<\/p>\n\n\n\n<p>spontaneous neuronal spikes were not spatially organized but were correlated<\/p>\n\n\n\n<p>with the OR types. Receptor substitution experiments demonstrated that ORs<\/p>\n\n\n\n<p>determine spontaneous activity patterns. Moreover, optogenetically<\/p>\n\n\n\n<p>differentiated patterns of neuronal activity induced specific expression of<\/p>\n\n\n\n<p>the corresponding axon-sorting molecules and regulated axonal segregation.<\/p>\n\n\n\n<p>Thus, OR-dependent temporal patterns of spontaneous activity play<\/p>\n\n\n\n<p>instructive roles in generating the combinatorial code of axon-sorting<\/p>\n\n\n\n<p>molecules during olfactory map formation.<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31171707\">https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/31171707<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.mh4vzihgqxo7_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mh4vzihgqxo7\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.mh4vzihgqxo7\"><\/a>2019\u5e747\u670810\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC190710@\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD \u3075\u307e<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\uff12\u5e74\u306e\u5e03\u9593\u3068\u7533\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Migraine-Associated TRESK Mutations Increase Neuronal Excitability<\/p>\n\n\n\n<p>through Alternative Translation<\/p>\n\n\n\n<p>Initiation and Inhibition of TREK<\/p>\n\n\n\n<p>Perrine Royal, Alba Andres-Bilbe, Pablo A\u00b4 valos Prado, &#8230;, Xavier<\/p>\n\n\n\n<p>Gasull, Joshua Levitz, Guillaume Sandoz<\/p>\n\n\n\n<p>Neuron. 2019 Jan 16;101(2):232-245.e6.<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u304f\u3060\u3055\u3044\u3002<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.neuron.2018.11.039\">https:\/\/doi.org\/10.1016\/j.neuron.2018.11.039<\/a><\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5e03\u9593\u5bdb\u7ae0<\/p>\n\n\n\n<p>\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66 \u9ebb\u9154\u79d1\u5b66\u8b1b\u5ea7<\/p>\n\n\n\n<p>\u9ebb\u9154\u79d1\u5b66\u30fb\u4fb5\u8972\u9632\u5fa1\u533b\u5b66\u5927\u5b66\u9662<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8<\/p>\n\n\n\n<p>\u5e03\u9593 \u5bdb\u7ae0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.pbtfegvw4hx2_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pbtfegvw4hx2\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.pbtfegvw4hx2\"><\/a>2019\u5e747\u6708 3\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC190703@\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD<\/p>\n\n\n\n<p>\u4eca\u9031\u306eNeuroclub\u3067\u306f\u3001\u6700\u8fd1\u51fa\u305f\u81ea\u5206\u305f\u3061\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u810a\u9ac4\u5c0f\u8133\u5909\u6027\u75c742\u578b\u306e\u75c7\u4f8b\u3068\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u89e3\u6790\u3067\u3059\u3002<\/p>\n\n\n\n<p>Ataxic phenotype with altered CaV3.1 channel property in a mouse model<\/p>\n\n\n\n<p>for spinocerebellar ataxia 42.<\/p>\n\n\n\n<p>Hashiguchi et al. Neurobiol Dis. 2019 Jun 20:104516.<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>\u77f3\u5ddd\u592a\u90ce<\/p>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.70qz2hjeeiws_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.70qz2hjeeiws\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.70qz2hjeeiws\"><\/a>2019\u5e746\u670826\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC190626@\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u96624\u5e74\u306e\u77e2\u5cf6\u611b\u7f8e\u3067\u3059\u3002<\/p>\n\n\n\n<p>6\u670826\u65e5\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Basolateral amygdala input to the medial prefrontal cortex controls<\/p>\n\n\n\n<p>obsessive-compulsive disorder-like checking behavior.<\/p>\n\n\n\n<p>Sun T, Song Z, Tian Y, Tian W, Zhu C, Ji G, Luo Y, Chen S, Wang L, Mao Y,<\/p>\n\n\n\n<p>Xie W, Zhong H, Zhao F, Luo MH, Tao W, Wang H, Li J, Li J, Zhou J, Wang<\/p>\n\n\n\n<p>K, Zhang Z.<\/p>\n\n\n\n<p>Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3799-3804. doi: 10.1073\/<\/p>\n\n\n\n<p>pnas.1814292116. Epub 2019 Feb 11.<\/p>\n\n\n\n<p>PMID: 30808765<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>Obsessive-compulsive disorder (OCD) affects \u223c1 to 3% of the world\u2019s<\/p>\n\n\n\n<p>population. However, the neural mechanisms underlying the excessive<\/p>\n\n\n\n<p>checking symptoms in OCD are not fully understood. Using viral neuronal<\/p>\n\n\n\n<p>tracing in mice, we found that glutamatergic neurons from the<\/p>\n\n\n\n<p>basolateral amygdala (BLAGlu) project onto both medial prefrontal cortex<\/p>\n\n\n\n<p>glutamate (mPFCGlu) and GABA (mPFCGABA) neurons that locally innervate<\/p>\n\n\n\n<p>mPFCGlu neurons. Next, we developed an OCD checking mouse model with<\/p>\n\n\n\n<p>quinpirole-induced repetitive checking behaviors. This model<\/p>\n\n\n\n<p>demonstrated decreased glutamatergic mPFC microcircuit activity<\/p>\n\n\n\n<p>regulated by enhanced BLAGlu inputs. Optical or chemogenetic<\/p>\n\n\n\n<p>manipulations of this maladaptive circuitry restored the behavioral<\/p>\n\n\n\n<p>response. These findings were verified in a mouse<\/p>\n\n\n\n<p>functionalmagneticresonanceimaging(fMRI)study,inwhich the BLA\u2013mPFC<\/p>\n\n\n\n<p>functional connectivity was increased in OCD mice. Together, these<\/p>\n\n\n\n<p>findings define a unique BLAGlu\u2192mPFCGABA\u2192Glu circuit that controls the<\/p>\n\n\n\n<p>checking symptoms of OCD.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.lail4wrp8o2a_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lail4wrp8o2a\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.lail4wrp8o2a\"><\/a>2019\u5e746\u670819\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC190619@\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD<\/p>\n\n\n\n<p>\u660e\u65e5\u306e\u30cb\u30e5\u30fc\u30ed\u30af\u30e9\u30d6\u306e\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u306e\u5927\u5b66\u9662\u306e\u6d6e\u5730\u91cc\u4f73\u5b50\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u6240\u306f\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3055\u308c\u308b\u65b9\u306f\u3053\u3061\u3089\u304b\u3089\u2193<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>TLR4 deficiency abrogated widespread tactile allodynia, but not<\/p>\n\n\n\n<p>widespread thermal hyperalgesia and trigeminal neuropathic pain after<\/p>\n\n\n\n<p>partial infraorbital nerve transection.<\/p>\n\n\n\n<p>Hu TT, Wang RR, Tang YY, Wu YX, Yu J, Hou WW, Lou GD, Zhou YD, Zhang SH,<\/p>\n\n\n\n<p>Chen Z.<\/p>\n\n\n\n<p>Pain. 2018 Feb;159(2):273-283. doi: 10.1097\/j.pain.0000000000001100.<\/p>\n\n\n\n<p>PMID: 29112008 DOI: 10.1097\/j.pain.0000000000001100<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Pain sensitization after partial infraorbital nerve transection (p-IONX)<\/p>\n\n\n\n<p>in mice not only presents in orofacial region, but also spreads to<\/p>\n\n\n\n<p>distant body parts. The roles of toll-like receptor 4 (TLR4) in<\/p>\n\n\n\n<p>orofacial pain and the spreading process are still unclear. Here, we<\/p>\n\n\n\n<p>found that mice with deficient TLR4 because of Tr4 gene point mutation (<\/p>\n\n\n\n<p>C3H\/HeJ) or spontaneous deletion (C57BL\/10ScNJ) developed tactile<\/p>\n\n\n\n<p>allodynia and thermal hyperalgesia in the vibrissal pad in a parallel<\/p>\n\n\n\n<p>way to their respective wild types (C3HeB\/FeJ or C57BL\/6J) after p-IONX.<\/p>\n\n\n\n<p>However, allodynia in the hind paw was absent in mice with TLR4<\/p>\n\n\n\n<p>deficiency. Pharmacological antagonism of TLR4 with LPS-RS, administered<\/p>\n\n\n\n<p>either intracisternally or intrathecally, abrogated allodynia in the<\/p>\n\n\n\n<p>hind paw without affecting the hypersensitivity in the vibrissal pad and<\/p>\n\n\n\n<p>hyperalgesia in the hind paw. Although TNF-\u03b1 expression was upregulated<\/p>\n\n\n\n<p>in both the medulla and lumbar cord, the expression of TLR4 downstream<\/p>\n\n\n\n<p>molecule MyD88 increased only in the lumbar cord after p-IONX in wild<\/p>\n\n\n\n<p>types. By contrast, hind paw hypersensitivity after partial sciatic<\/p>\n\n\n\n<p>nerve ligation was significantly attenuated by TLR4 deletion. The<\/p>\n\n\n\n<p>hypersensitivity, which did not spread to the vibrissal pad, was<\/p>\n\n\n\n<p>accompanied with upregulation of MyD88 in the lumbar cord rather than in<\/p>\n\n\n\n<p>the medulla. These results suggest that TLR4 participates in the spread<\/p>\n\n\n\n<p>of allodynia component of orofacial pain to distant body sites, but not<\/p>\n\n\n\n<p>trigeminal neuropathic pain or the spread of its hyperalgesia component.<\/p>\n\n\n\n<p>This study suggests that TLR4 may serve as a potential target for the<\/p>\n\n\n\n<p>management of widespread allodynia associated with orofacial pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.c0rvg2b7lfn8_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c0rvg2b7lfn8\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.c0rvg2b7lfn8\"><\/a>2019\u5e746\u670812\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>6\u670812\u65e5\u306e\u7d39\u4ecb\u8ad6\u6587<\/p>\n\n\n\n<p>\u7686\u69d8\u3001<\/p>\n\n\n\n<p>\u660e\u65e5\u306f\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u3053\u3092\u30af\u30ea\u30c3\u30af\u3057\u3066\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u3000\u5fd7\u725f\u7530\u7f8e\u4f50<\/p>\n\n\n\n<p>Predictive and reactive reward signals conveyed by climbing fiber inputs to cerebellar Purkinje cells.<\/p>\n\n\n\n<p>Kostadinov D, Beau M, Pozo MB, H\u00e4usser M.<\/p>\n\n\n\n<p>Nat Neurosci. 2019 Jun;22(6):950-962. doi: 10.1038\/s41593-019-0381-8. Epub 2019 Apr 29.<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>There is increasing evidence for a cerebellar contribution to cognitive processing, but the specific input pathways conveying this information remain unclear. We probed the role of climbing fiber inputs to Purkinje cells in generating and evaluating predictions about associations between motor actions, sensory stimuli and reward. We trained mice to perform a visuomotor integration task to receive a reward and interleaved cued and random rewards between task trials. Using two-photon calcium imaging and Neuropixels probe recordings of Purkinje cell activity, we show that climbing fibers signal reward expectation, delivery and omission. These signals map onto cerebellar microzones, with reward delivery activating some microzones and suppressing others, and with reward omission activating both reward-activated and reward-suppressed microzones. Moreover, responses to predictable rewards are progressively suppressed during learning. Our findings elucidate a specific input pathway for cerebellar contributions to reward signaling and provide a mechanistic link between cerebellar activity and the creation and evaluation of predictions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.7hmhzncvglxt_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7hmhzncvglxt\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7hmhzncvglxt\"><\/a>2019\u5e746\u6708 5\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190605@\u5927\u5b66\uff11\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD<\/p>\n\n\n\n<p>Insular cortex processes aversive somatosensory information and is crucial for threat learning<\/p>\n\n\n\n<p>Introduced by Mathieu Pich\u00e9<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.bmc0wqdrp7qc_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.bmc0wqdrp7qc\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.bmc0wqdrp7qc\"><\/a>2019\u5e745\u670822\u65e5<\/h2>\n\n\n\n<p>\u62c5\u5f53\u52a0\u85e4<\/p>\n\n\n\n<p>5\/22\u306f\u4ee5\u4e0b\u306eeNeuro\u306b\u8f09\u3063\u305f\uff12\u5831\u3092\u4f75\u305b\u3066\u7d39\u4ecb\u3057\u307e\u3059\u3002\uff11\u5831\u306f2017\u5e74\u306eGereau\u3068Bruchas\u305f\u3061\u306e\u8ad6\u6587\u3001\u3082\u3046\uff11\u5831\u306f\u6700\u8fd1\u306eBrown\u305f\u3061\u306e\u8ad6\u6587\u3067\u3059\u3002<\/p>\n\n\n\n<p>Divergent Modulation of Nociception by Glutamatergic and GABAergic Neuronal Subpopulations in the Periaqueductal Gray<\/p>\n\n\n\n<p>Vijay K. Samineni, Jose G. Grajales-Reyes, Bryan A. Copits, Daniel E. O\u2019Brien, Sarah L. Trigg, Adrian M. Gomez, Michael R. Bruchas and Robert W. Gereau<\/p>\n\n\n\n<p>eNeuro 17 March 2017, 4 (2) ENEURO.0129-16.2017<\/p>\n\n\n\n<p>DOI: https:\/\/doi.org\/10.1523\/ENEURO.0129-16.2017<\/p>\n\n\n\n<p>The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray\/Dorsal Raphe: Separating Analgesia and Anxiety<\/p>\n\n\n\n<p>Norman E. Taylor, JunZhu Pei, Jie Zhang, Ksenia Y. Vlasov, Trevor Davis, Emma Taylor, Feng-Ju Weng, Christa J. Van Dort, Ken Solt and Emery N. Brown<\/p>\n\n\n\n<p>eNeuro 12 February 2019, 6 (1) ENEURO.0018-18.2019<\/p>\n\n\n\n<p>DOI: https:\/\/doi.org\/10.1523\/ENEURO.0018-18.2019<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.9s7ftiokktol_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.9s7ftiokktol\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.9s7ftiokktol\"><\/a>2019\u5e745\u670815\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190515\uff20\u5927\u5b662\u53f7\u99281403\u4f1a\u8b70\u5ba4\u3000\u62c5\u5f53\u5965\u7530<\/p>\n\n\n\n<p>5\/15\u306eNeuroClub\u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep<\/p>\n\n\n\n<p>Li-Feng Jiang-Xie, Luping Yin, Shengli Zhao, Vincent Prevosto, Bao-Xia Han, Kafui Dzirasa, and\u3000Fan Wang<\/p>\n\n\n\n<p>Neuron April 18, 2019<\/p>\n\n\n\n<p>PMID: 31006556<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\u751f<\/p>\n\n\n\n<p>\u5965\u7530\u5d07\u96c4<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.7kr2x1efqv4d_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7kr2x1efqv4d\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.7kr2x1efqv4d\"><\/a>2019\u5e745\u6708 8\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190508\uff20\u5927\u5b662\u53f7\u99281403\u4f1a\u8b70\u5ba4\u3000\u62c5\u5f53\u4e2d\u6751<\/p>\n\n\n\n<p>5\u67088\u65e5\u306eNeuroclub\u3067\u306f\u3001\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Underpinning heterogeneity in synaptic transmission by presynaptic<\/p>\n\n\n\n<p>ensembles of distinct morphological modules.<\/p>\n\n\n\n<p>Fekete A, Nakamura Y, Yang YM, Herlitze S, Mark MD, DiGregorio DA, Wang<\/p>\n\n\n\n<p>LY.<\/p>\n\n\n\n<p>Nat Commun. 2019 10:826.<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Synaptic heterogeneity is widely observed but its underpinnings remain<\/p>\n\n\n\n<p>elusive. We addressed this issue using mature calyx of Held synapses<\/p>\n\n\n\n<p>whose numbers of bouton-like swellings on stalks of the nerve terminals<\/p>\n\n\n\n<p>inversely correlate with release probability (Pr). We examined<\/p>\n\n\n\n<p>presynaptic Ca2+ currents and transients, topology of fluorescently<\/p>\n\n\n\n<p>tagged knock-in Ca2+ channels, and Ca2+ channel-synaptic vesicle (SV)<\/p>\n\n\n\n<p>coupling distance using Ca2+ chelator and inhibitor of septin cytomatrix<\/p>\n\n\n\n<p>in morphologically diverse synapses. We found that larger clusters of<\/p>\n\n\n\n<p>Ca2+ channels with tighter coupling distance to SVs elevate Pr in stalks,<\/p>\n\n\n\n<p>while smaller clusters with looser coupling distance lower Pr in<\/p>\n\n\n\n<p>swellings. Septin is a molecular determinant of the differences in<\/p>\n\n\n\n<p>coupling distance. Supported by numerical simulations, we propose that<\/p>\n\n\n\n<p>varying the ensemble of two morphological modules containing distinct<\/p>\n\n\n\n<p>Ca2+ channel-SV topographies diversifies Pr in the terminal, thereby<\/p>\n\n\n\n<p>establishing a morpho-functional continuum that expands the coding<\/p>\n\n\n\n<p>capacity within a single synapse population.<\/p>\n\n\n\n<p><a href=\"https:\/\/rdcu.be\/bniFN\">https:\/\/rdcu.be\/bniFN<\/a><\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.smdbvl9uddp_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.smdbvl9uddp\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.smdbvl9uddp\"><\/a>2019\u5e744\u670824\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190424\uff20\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD\u3000\u62c5\u5f53\u9ad8\u6a4b<\/p>\n\n\n\n<p>\u6765\u90314\u670824\u65e5\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u9ad8\u6a4b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u6240\u306f\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u8ad6\u6587\u306f\u6dfb\u4ed8\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3055\u308c\u308b\u65b9\u306f\u3053\u3061\u3089\u304b\u3089\u2193<\/p>\n\n\n\n<p><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0515-2\">https:\/\/www.nature.com\/articles\/s41586-018-0515-2<\/a><\/p>\n\n\n\n<p>Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.<\/p>\n\n\n\n<p>Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z.<\/p>\n\n\n\n<p>Nature. 2018 Sep;561(7724):547-550. doi: 10.1038\/s41586-018-0515-2. Epub 2018 Sep 12.<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Current models of somatosensory perception emphasize transmission from primary sensory neurons to the spinal cord and on to the brain. Mental influence on perception is largely assumed to occur locally within the brain. Here we investigate whether sensory inflow through the spinal cord undergoes direct top-down control by the cortex. Although the corticospinal tract (CST) is traditionally viewed as a primary motor pathway, a subset of corticospinal neurons (CSNs) originating in the primary and secondary somatosensory cortex directly innervate the spinal dorsal horn via CST axons. Either reduction in somatosensory CSN activity or transection of the CST in mice selectively impairs behavioural responses to light touch without altering responses to noxious stimuli. Moreover, such CSN manipulation greatly attenuates tactile allodynia in a model of peripheral neuropathic pain. Tactile stimulation activates somatosensory CSNs, and their corticospinal projections facilitate light-touch-evoked activity of cholecystokinin interneurons in the deep dorsal horn. This touch-driven feed-forward spinal-cortical-spinal sensitization loop is important for the recruitment of spinal nociceptive neurons under tactile allodynia. These results reveal direct cortical modulation of normal and pathological tactile sensory processing in the spinal cord and open up opportunities for new treatments for neuropathic pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.4ky97hh6uuad_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.4ky97hh6uuad\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.4ky97hh6uuad\"><\/a>2019\u5e744\u670817\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190417\uff20\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD\u3000\u62c5\u5f53\u6709\u6751<\/p>\n\n\n\n<p>\u6765\u90314\u670817\u65e5\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u6709\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u6240\u306f\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6709\u6751\u62dd<\/p>\n\n\n\n<p>Oxytocin modulates social value representations in the amygdala.<\/p>\n\n\n\n<p>Liu Y, Li S, Lin W, Li W, Yan X, Wang X, Pan X, Rutledge RB, Ma Y.<\/p>\n\n\n\n<p>Nat Neurosci. 2019 Apr;22(4):633-641. PMID: 30911182<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Humans exhibit considerable variation in how they value their own interest relative to the interests of others. Deciphering the neural codes representing potential rewards for self and others is crucial for understanding social decision-making. Here we integrate computational modeling with functional magnetic resonance imaging to investigate the neural representation of social value and the modulation by oxytocin, a nine-amino acid neuropeptide, in participants evaluating monetary allocations to self and other (self\u2013other allocations). We found that an individual\u2019s preferred self\u2013other allocation serves as a reference point for computing the value of potential self\u2013other allocations. In more prosocial participants, amygdala activity encoded a social-value-distance signal; that is, the value dissimilarity between potential and preferred allocations. Intranasal oxytocin administration amplified this amygdala representation and increased prosocial behavior in more individualistic participants but not in more prosocial ones. Our results reveal a neurocomputational mechanism underlying social-value representations and suggest that oxytocin may promote prosociality by modulating social-value representations in the amygdala.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.6cvt0yt6q9kv_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6cvt0yt6q9kv\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6cvt0yt6q9kv\"><\/a>2019\u5e744\u670810\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>4\u670810\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002\u304a\u624b\u6570\u3067\u3059\u304c\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u306f\u5404\u81ea\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>4\u67086\u65e5<\/p>\n\n\n\n<p>\u7c7e\u5c71\u4fca\u5f66<\/p>\n\n\n\n<p>Cholinergic Interneurons Amplify Thalamostriatal Excitation of Striatal<\/p>\n\n\n\n<p>Indirect Pathway Neurons in Parkinson&#8217;s Disease Models.<\/p>\n\n\n\n<p>by<\/p>\n\n\n\n<p>Tanimura A, Du Y, Kondapalli J, Wokosin DL, Surmeier DJ.<\/p>\n\n\n\n<p>Neuron 101:444-458, 2019.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.had1ybhng8vo_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.had1ybhng8vo\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.had1ybhng8vo\"><\/a>2019\u5e744\u6708 2\u65e5 (\u706b)<\/h2>\n\n\n\n<p>2019 Spring International Conference presented by Jikei Center for Neuroscience of Pain<\/p>\n\n\n\n<p>flyer pdf file<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.no3z7to2iydf_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.no3z7to2iydf\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.no3z7to2iydf\"><\/a>2019\u5e743\u670827\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190327\uff20\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD\u3000\u62c5\u5f53 \u91ce\u53e3<\/p>\n\n\n\n<p>3\/27\u62c5\u5f53\u306e\u91ce\u53e3\uff08\u795e\u7d4c\u79d1\u5b66\u30fb\u8a2a\u554f\u7814\u7a76\u54e1\uff09\u3067\u3059\uff0e<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304f\u4e88\u5b9a\u3067\u3059\uff0e\uff08\u5834\u6240\u306f\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002\uff09<\/p>\n\n\n\n<p>GABA and glutamate neurons in the VTA regulate sleep and wakefulness.<\/p>\n\n\n\n<p>Yu X, Li W, Ma Y, Tossell K, Harris JJ, Harding EC, Ba W, Miracca G,<\/p>\n\n\n\n<p>Wang D, Li L, Guo J, Chen M, Li Y, Yustos R, Vyssotski AL, Burdakov D,<\/p>\n\n\n\n<p>Yang Q, Dong H, Franks NP, Wisden W.<\/p>\n\n\n\n<p>Nat Neurosci. 2019 Jan;22(1):106-119. doi: 10.1038\/s41593-018-0288-9.<\/p>\n\n\n\n<p>Epub 2018 Dec 17.<\/p>\n\n\n\n<p>PMID: 30559475<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>We screened for novel circuits in the mouse brain that promote<\/p>\n\n\n\n<p>wakefulness. Chemogenetic activation experiments and<\/p>\n\n\n\n<p>electroencephalogram recordings pointed to glutamatergic\/nitrergic (NOS1)<\/p>\n\n\n\n<p>and GABAergic neurons in the ventral tegmental area (VTA). Activating<\/p>\n\n\n\n<p>glutamatergic\/NOS1 neurons, which were wake- and rapid eye movement (REM)<\/p>\n\n\n\n<p>sleep-active, produced wakefulness through projections to the nucleus<\/p>\n\n\n\n<p>accumbens and the lateral hypothalamus. Lesioning the glutamate cells<\/p>\n\n\n\n<p>impaired the consolidation of wakefulness. By contrast, activation of<\/p>\n\n\n\n<p>GABAergic VTA neurons elicited long-lasting non-rapid-eye-movement-like<\/p>\n\n\n\n<p>sleep resembling sedation. Lesioning these neurons produced an increase<\/p>\n\n\n\n<p>in wakefulness that persisted for at least 4\u2009months. Surprisingly, these<\/p>\n\n\n\n<p>VTA GABAergic neurons were wake- and REM sleep-active. We suggest that<\/p>\n\n\n\n<p>GABAergic VTA neurons may limit wakefulness by inhibiting the arousal-<\/p>\n\n\n\n<p>promoting VTA glutamatergic and\/or dopaminergic neurons and through<\/p>\n\n\n\n<p>projections to the lateral hypothalamus. Thus, in addition to its<\/p>\n\n\n\n<p>contribution to goal- and reward-directed behaviors, the VTA has a role<\/p>\n\n\n\n<p>in regulating sleep and wakefulness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.ps34gsado2qa_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ps34gsado2qa\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ps34gsado2qa\"><\/a>2019\u5e743\u670820\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>NC20190320\uff20\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD\u3000\u62c5\u5f53\u6749\u6751<\/p>\n\n\n\n<p>Neuroclub\u306e\u7686\u69d8<\/p>\n\n\n\n<p>\u6765\u90313\u670820\u65e5\u62c5\u5f53\u306e\u795e\u7d4c\u79d1\u5b66\u306e\u6749\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9\u3092\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u6240\u306f\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8<\/p>\n\n\n\n<p>\u6749\u6751\u5f25\u6075<\/p>\n\n\n\n<p>Identifying the pathways required for coping behaviours associated with<\/p>\n\n\n\n<p>sustained pain.<\/p>\n\n\n\n<p>Huang T, Lin SH, Malewicz NM, Zhang Y, Zhang Y, Goulding M, LaMotte RH,<\/p>\n\n\n\n<p>Ma Q.<\/p>\n\n\n\n<p>Nature. 2019 Jan;565(7737):86-90.<\/p>\n\n\n\n<p>PMID: 30532001<\/p>\n\n\n\n<p>&nbsp;Nature\u306e\u30da\u30fc\u30b8\u304b\u3089\u30c0\u30a6\u30f3\u30ed\u30fc\u30c9<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>Animals and humans display two types of response to noxious stimuli. The<\/p>\n\n\n\n<p>first includes reflexive defensive responses that prevent or limit<\/p>\n\n\n\n<p>injury; a well-known example of these responses is the quick withdrawal<\/p>\n\n\n\n<p>of one&#8217;s hand upon touching a hot object. When the first-line response<\/p>\n\n\n\n<p>fails to prevent tissue damage (for example, a finger is burnt), the<\/p>\n\n\n\n<p>resulting pain invokes a second-line coping response-such as licking the<\/p>\n\n\n\n<p>injured area to soothe suffering. However, the underlying neural<\/p>\n\n\n\n<p>circuits that drive these two strings of behaviour remain poorly<\/p>\n\n\n\n<p>understood. Here we show in mice that spinal neurons marked by<\/p>\n\n\n\n<p>coexpression of TAC1Cre and LBX1Flpo drive coping responses associated<\/p>\n\n\n\n<p>with pain. Ablation of these spinal neurons led to the loss of both<\/p>\n\n\n\n<p>persistent licking and conditioned aversion evoked by stimuli (including<\/p>\n\n\n\n<p>skin pinching and burn injury) that-in humans-produce sustained pain,<\/p>\n\n\n\n<p>without affecting any of the reflexive defensive reactions that we<\/p>\n\n\n\n<p>tested. This selective indifference to sustained pain resembles the<\/p>\n\n\n\n<p>phenotype seen in humans with lesions of medial thalamic nuclei1-3.<\/p>\n\n\n\n<p>Consistently, spinal TAC1-lineage neurons are connected to medial<\/p>\n\n\n\n<p>thalamic nuclei by direct projections and via indirect routes through<\/p>\n\n\n\n<p>the superior lateral parabrachial nuclei. Furthermore, the anatomical<\/p>\n\n\n\n<p>and functional segregation observed at the spinal level also applies to<\/p>\n\n\n\n<p>primary sensory neurons. For example, in response to noxious mechanical<\/p>\n\n\n\n<p>stimuli, MRGPRD- and TRPV1-positive nociceptors are required to elicit<\/p>\n\n\n\n<p>reflexive and coping responses, respectively. Our study therefore<\/p>\n\n\n\n<p>reveals a fundamental subdivision within the cutaneous somatosensory<\/p>\n\n\n\n<p>system, and challenges the validity of using reflexive defensive<\/p>\n\n\n\n<p>responses to measure sustained pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.1j4ia55e9m3z_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1j4ia55e9m3z\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1j4ia55e9m3z\"><\/a>2019\u5e743\u6708 6\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>2019\u5e743\u67086\u65e5Neuroclub<\/p>\n\n\n\n<p>Neuroclub\u306e\u7686\u3055\u307e<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u306e\u5927\u5b66\u96621\u5e74\u76ee\u306e\u6d6e\u5730\u3067\u3059\u3002<\/p>\n\n\n\n<p>3\u67086\u65e5\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002PDF\u3067\u6dfb\u4ed8\u3057\u3066\u304a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9023\u7d61\u304c\u9045\u304f\u306a\u308a\u7533\u3057\u8a33\u3042\u308a\u307e\u305b\u3093\u3002\u3069\u3046\u305e\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Endogenous opioids regulate moment-to-moment neuronal communication and<\/p>\n\n\n\n<p>excitability.<\/p>\n\n\n\n<p>Winters BL, Gregoriou GC, Kissiwaa SA, Wells OA, Medagoda DI, Hermes SM,<\/p>\n\n\n\n<p>Burford NT, Alt A, Aicher SA, Bagley EE.<\/p>\n\n\n\n<p>Nat Commun. 2017 Mar 22;8:14611.<\/p>\n\n\n\n<p>PMID: 28327612 PMCID: PMC5364458 DOI: 10.1038\/ncomms14611<\/p>\n\n\n\n<p>\u6d6e\u5730\u91cc\u4f73\u5b50<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.l5u2hhu3zwen_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l5u2hhu3zwen\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.l5u2hhu3zwen\"><\/a>2019\u5e742\u670820\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>2\u6708\uff12\uff10\u65e5\u7d39\u4ecb\u8ad6\u6587 \u5e03\u9593<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u9662\uff11\u5e74\u5e03\u9593\u3068\u7533\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia<\/p>\n\n\n\n<p>by the Antidepressant Drugs<\/p>\n\n\n\n<p>Duloxetine and Amitriptyline<\/p>\n\n\n\n<p>Me\u00b4lanie Kremer, RIpek Yalcin, Yannick Goumon, Xavier Wurtz, Laurent<\/p>\n\n\n\n<p>Nexon, Dorothe\u00b4e Daniel, Salim Megat,1hian A. Ceredig, Carl Ernst,<\/p>\n\n\n\n<p>XGustavo Turecki, Virginie Chavant, Jean-Franc\u00b8ois The\u00b4roux, Adrien<\/p>\n\n\n\n<p>Lacaud,Lauriane-Elisabeth Joganah, Vincent Lelievre, Dominique Massotte,<\/p>\n\n\n\n<p>XPierre-Eric Lutz, XRalf Gilsbach, Eric Salvat, and Michel Barrot<\/p>\n\n\n\n<p>The Journal of Neuroscience, November 14, 2018 \u2022 38(46):9934 \u20139954<\/p>\n\n\n\n<p>\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66 \u9ebb\u9154\u79d1\u5b66\u8b1b\u5ea7<\/p>\n\n\n\n<p>\u9ebb\u9154\u79d1\u5b66\u30fb\u4fb5\u8972\u9632\u5fa1\u533b\u5b66\u5927\u5b66\u9662<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8<\/p>\n\n\n\n<p>\u5e03\u9593 \u5bdb\u7ae0<\/p>\n\n\n\n<p>\u3012105-8461 \u6771\u4eac\u90fd\u6e2f\u533a\u897f\u65b0\u6a4b3-25-8<\/p>\n\n\n\n<p>TEL : 03-3433-1111 (\u5185\u7dda:2396)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.aaazrl1f61ix_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.aaazrl1f61ix\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.aaazrl1f61ix\"><\/a>2019\u5e742\u670813\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>2019\u5e742\u670813\u65e5\u7d39\u4ecb\u8ad6\u6587\uff08\u52a0\u85e4\uff09<\/p>\n\n\n\n<p>\u3054\u9023\u7d61\u304c\u9045\u308c\u307e\u3057\u305f\u30022\u670813\u65e5\u62c5\u5f53\u306e\u52a0\u85e4\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u5927\u5909\u7533\u3057\u8a33\u3042\u308a\u307e\u305b\u3093\u304c\u30012\u670813\u65e5\u306eNeuroClub\u306e\u958b\u59cb\u309210:20\u304b\u3089\u306b\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3088\u3046\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u5834\u6240\u306f\u5927\u5b661\u53f7\u992817\u968e\u30ab\u30f3\u30d5\u30a1CD\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6642\u9593\u3082\u77ed\u3044\u306e\u3067\u982d\u8db3\u985e\u306e\u7c21\u5358\u306a\u884c\u52d5\u3060\u3051\u306e\u77ed\u3044\u8ad6\u6587\u3092\uff12\u5831\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u52a0\u85e4\u7dcf\u592b<\/p>\n\n\n\n<p>Evidence of episodic-like memory in cuttlefish, Christelle Jozet-Alves, Marion Bertin, Nicola S. Clayton<\/p>\n\n\n\n<p>Open ArchiveDOI:https:\/\/doi.org\/10.1016\/j.cub.2013.10.021<\/p>\n\n\n\n<p>VOLUME 23, ISSUE 23, PR1033-R1035, DECEMBER 02, 2013<\/p>\n\n\n\n<p>Richter JN, Hochner B, Kuba MJ (2016)Pull or Push? Octopuses Solve a Puzzle Problem.PLoS ONE 11(3): e0152048. doi:10.1371\/journal.pone.0152048<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.vnmtqcqlsbmc_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.vnmtqcqlsbmc\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.vnmtqcqlsbmc\"><\/a>2019\u5e742\u6708 6\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>2\u67086\u65e5\u7d39\u4ecb\u8ad6\u6587<\/p>\n\n\n\n<p>\u4eca\u9031\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u96e3\u3057\u304f\u306a\u3044\u306e\u3067\u3001\u914d\u5c5e\u306e\u5b66\u751f\u3055\u3093\u3082\u7406\u89e3\u3067\u304d\u308b\u5185\u5bb9\u3060\u308d\u3046\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>1\u30da\u30fc\u30b8\u76ee\u304c\u30c0\u30a4\u30b8\u30a7\u30b9\u30c8\u7248\u306a\u306e\u3067\u3001\u305d\u308c\u3060\u3051\u3067\u3082\u6982\u8981\u306f\u63b4\u3081\u308b\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Cerebellar modulation of the reward circuitry and social behavior.<\/p>\n\n\n\n<p>Carta I, Chen CH, Schott AL, Dorizan S, Khodakhah K.<\/p>\n\n\n\n<p>Science. 2019 Jan 18;363(6424).<\/p>\n\n\n\n<p><a href=\"https:\/\/www.dropbox.com\/s\/kvunft4funs5qty\/JC190206Ishikawa.pdf?dl=0\">https:\/\/www.dropbox.com\/s\/kvunft4funs5qty\/JC190206Ishikawa.pdf?dl=0<\/a><\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>The cerebellum has been implicated in a number of nonmotor mental disorders such as autism spectrum disorder, schizophrenia, and addiction. However, its contribution to these disorders is not well understood. In mice, we found that the cerebellum sends direct excitatory projections to the ventral tegmental area (VTA), one of the brain regions that processes and encodes reward. Optogenetic activation of the cerebello-VTA projections was rewarding and, in a three-chamber social task, these projections were more active when the animal explored the social chamber. Intriguingly, activity in the cerebello-VTA pathway was required for the mice to show social preference in this task. Our data delineate a major, previously unappreciated role for the cerebellum in controlling the reward circuitry and social behavior.<\/p>\n\n\n\n<p>\u77f3\u5ddd\u592a\u90ce<\/p>\n\n\n\n<p>\u6771\u4eac\u6148\u6075\u4f1a\u533b\u79d1\u5927\u5b66\u3000\u85ac\u7406\u5b66\u8b1b\u5ea7<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.eq2lrgh0e21e_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.eq2lrgh0e21e\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.eq2lrgh0e21e\"><\/a>2019\u5e741\u670830\u65e5 (\u6c34)<\/h2>\n\n\n\n<p>1\u670830\u65e5\u7d39\u4ecb\u8ad6\u6587<\/p>\n\n\n\n<p>\u795e\u7d4c\u79d1\u5b66\u7814\u7a76\u90e8\u5927\u5b66\u96623\u5e74\u306e\u77e2\u5cf6\u611b\u7f8e\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u30001\u670830\u65e5\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304d\u307e\u3059\u3002\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Neurochem Int. 2019 Jan 8. pii: S0197-0186(18)30506-0. doi: 10.1016\/j.<\/p>\n\n\n\n<p>neuint.2019.01.007. [Epub ahead of print]<\/p>\n\n\n\n<p>Long-term application of cannabinoids leads to dissociation between<\/p>\n\n\n\n<p>changes in cAMP and modulation of GABAA receptors of mouse trigeminal<\/p>\n\n\n\n<p>sensory neurons.<\/p>\n\n\n\n<p>Celotto L1, Eroli F2, Nistri A3, Vilotti S4.<\/p>\n\n\n\n<p>Author information<\/p>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.m0lai377tan8_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m0lai377tan8\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.m0lai377tan8\"><\/a>\u3053\u306e\u9593\u7d04\uff18\u5e74\u306e\u8a18\u9332\u306f\u8ffd\u3063\u3066\u63b2\u793a\u3057\u307e\u3059\uff0e<\/h2>\n\n\n\n<p>&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;&#8212;-<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.yqacnc69fy49_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yqacnc69fy49\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.yqacnc69fy49\"><\/a>2010\u5e7411\u670830\u65e5<\/h2>\n\n\n\n<p>\u4eca\u56de\u62c5\u5f53\u306e\u5965\u6d25\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>&nbsp;Keller AF, Beggs S, Salter MW, De Koninck Y. Transformation of the output of spinal lamina I neurons after nerve injury and microglia stimulation underlying neuropathic pain. Mol Pain. 2007 Sep 27;3:27. doi: 10.1186\/1744-8069-3-27. PMID: 17900333; PMCID: PMC2093929.&nbsp;<\/p>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n<p>\u5965\u6d25<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.e83ano2q9kvp_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e83ano2q9kvp\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e83ano2q9kvp\"><\/a>2010\u5e7411\u67089\u65e5<\/h2>\n\n\n\n<p>\u6b21\u56de\uff0811\/9\uff09Journal Club\u62c5\u5f53\u306e\u91ce\u53e3\uff08\u795e\u7d4c\u751f\u7406\uff09\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u300c\u5168\u9762\u7981\u7159\u304b\u5206\u7159\u3001\u5168\u4e8b\u696d\u6240\u3067\u7fa9\u52d9\u5316\u300d\u3068\u3059\u308b\u6cd5\u6848\uff08\u52b4\u50cd\u5b89\u5168\u885b\u751f\u6cd5\u6539\u6b63\u6848\uff09\u304c\u73fe\u5728<\/p>\n\n\n\n<p>\u958b\u50ac\u4e2d\u306e\u81e8\u6642\u56fd\u4f1a\u306b\u63d0\u51fa\u3055\u308c\u308b\u3068\u306e\u5831\u9053\u304c\u3042\u308a\u307e\u3057\u305f\u3002\u6cd5\u6848\u304c\u901a\u904e\u3057\u7fa9\u52d9\u5316\u3068\u306a\u308a\u3059<\/p>\n\n\n\n<p>\u3068\u3001\u4eca\u5f8c\u306f\u4e8b\u696d\u6240\uff08\u8077\u5834\uff09\u3067\u300c\u5168\u9762\u7981\u7159\u304b\u5206\u7159\u300d\u304c\u5b9f\u65bd\u3055\u308c\u3066\u3044\u308b\u304b\u5426\u304b\u306b\u3064\u3044\u3066\u3001<\/p>\n\n\n\n<p>\u52b4\u57fa\u7f72\u306e\u67fb\u5bdf\u304c\u5165\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3053\u308c\u3092\u6a5f\u306b\u7981\u7159\u3055\u308c\u308b\u65b9\u304c\u66f4\u306b\u5897\u3048\u308b\u306e\u304b\u306a\uff1f\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u3068\u3053\u308d\u3067\u3001\u300c\u305b\u3063\u304b\u304f\u9811\u5f35\u3063\u3066\u7981\u7159\u3057\u305f\u306e\u306b\u3001\u4f53\u91cd\u304c\u5897\u3048\u3066\u3057\u307e\u3063\u305f&#8230;\u300d\u3068\u3044\u3046\u82e6<\/p>\n\n\n\n<p>\u60c5\uff08\uff1f\uff09\u3092\u3088\u304f\u53d7\u3051\u307e\u3059\u3002\u7981\u7159\u5f8c\u4f53\u91cd\u5897\u52a0\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u307e\u3060\u826f\u304f\u5206\u304b\u3063\u3066\u3044\u307e\u305b\u3093<\/p>\n\n\n\n<p>\u304c\u3001\u3053\u306e\u73fe\u8c61\u306b\u95a2\u9023\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u308b\u3001\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u4eca\u56de\u306f\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>Nicotine decreases food intake through activation of POMC neurons.<\/p>\n\n\n\n<p>Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, G&amp;uuml;ndisch D, Diano<\/p>\n\n\n\n<p>S, De Biasi M, Horvath TL, Gao XB, Picciotto MR.<\/p>\n\n\n\n<p>Science. 2011 Jun 10;332(6035):1330-2.<\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencemag.org\/content\/332\/6035\/1330.short\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.sciencemag.org\/content\/332\/6035\/1330.short<\/a><\/p>\n\n\n\n<p>Full Text(PDF)<\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencemag.org\/content\/332\/6035\/1330.full.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.sciencemag.org\/content\/332\/6035\/1330.full.pdf<\/a><\/p>\n\n\n\n<p>Materials\/Methods, Supporting Text, Tables, Figures, and\/or References(PDF)<\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencemag.org\/content\/suppl\/2011\/06\/08\/332.6035.1330.DC1\/Mineur.SOM.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.sciencemag.org\/content\/suppl\/2011\/06\/08\/332.6035.1330.DC1\/Mineur.SOM.pdf<\/a><\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u81f4\u3057\u307e\u3059\u3002&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.e1mgs0vxpyka_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e1mgs0vxpyka\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.e1mgs0vxpyka\"><\/a>2010\u5e7411\u67082\u65e5<\/h2>\n\n\n\n<p>\u62c5\u5f53\uff1a\u52a0\u85e4<\/p>\n\n\n\n<p>Dear NeuroClubists,<\/p>\n\n\n\n<p>I will introduce the attached article.<\/p>\n\n\n\n<p>I visited this laboratory in May and October, twice a year!, and<\/p>\n\n\n\n<p>became convinced of the results.<\/p>\n\n\n\n<p>Wang F, Zhu J, Zhu H, Zhang Q, Lin Z, Hu H. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science. 2011 Nov 4;334(6056):693-7. doi: 10.1126\/science.1209951. Epub 2011 Sep 29. PMID: 21960531.&nbsp;<\/p>\n\n\n\n<p>The supporting online material file, which might not be very<\/p>\n\n\n\n<p>necessary, is too large to be sent as mail attachment and found at:<\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencemag.org\/content\/early\/2011\/09\/28\/science.1209951\/suppl\/DC1\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.sciencemag.org\/content\/early\/2011\/09\/28\/science.1209951\/suppl\/DC1<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.1cq7gl5lyls9_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1cq7gl5lyls9\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.1cq7gl5lyls9\"><\/a>2010\u5e7410\u670819\u65e5<\/h2>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u306e\u5ddd\u6751\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u6b21\u56deNeuroclub\u306e\u8ad6\u6587\u3092\u9001\u4ed8\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Marpegan L, Swanstrom AE, Chung K, Simon T, Haydon PG, Khan SK, Liu AC, Herzog ED, Beaul\u00e9 C. Circadian regulation of ATP release in astrocytes. J Neurosci. 2011 Jun 8;31(23):8342-50. doi: 10.1523\/JNEUROSCI.6537-10.2011. PMID: 21653839; PMCID: PMC3135876.&nbsp;<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u85ac\u7406\u5b66\u8b1b\u5ea7\u3000\u5ddd\u6751\u5c06\u4ec1&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.6oqe9i3xeq3k_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6oqe9i3xeq3k\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6oqe9i3xeq3k\"><\/a>2010\u5e7410\u670812\u65e5<\/h2>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u5b66\u6559\u5ba4\u306e\u4f50\u85e4\u3067\u3059\u3002<\/p>\n\n\n\n<p>10\u670812\u65e5\u306e NeuroClub \u3067\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3055\u305b\u3066\u3044\u305f\u3060\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p><a href=\"http:\/\/www.nature.com\/nature\/journal\/v468\/n7321\/pdf\/nature09559.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.nature.com\/nature\/journal\/v468\/n7321\/pdf\/nature09559.pdf<\/a><\/p>\n\n\n\n<p>Supplementary imformation<\/p>\n\n\n\n<p><a href=\"http:\/\/www.nature.com\/nature\/journal\/v468\/n7321\/extref\/nature09559-s1.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.nature.com\/nature\/journal\/v468\/n7321\/extref\/nature09559-s1.pdf<\/a><\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.6g4l9vkspf4o_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6g4l9vkspf4o\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.6g4l9vkspf4o\"><\/a>2010\u5e7410\u67085\u65e5<\/h2>\n\n\n\n<p>NeuroClub\u53c2\u52a0\u8005\u306e\u7686\u69d8<\/p>\n\n\n\n<p>\u6b21\u56deNC\u62c5\u5f53\u306e\u795e\u7d4c\u751f\u7406\u306e\u6c38\u702c\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u3054\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3092\u9001\u4ed8\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Di Castro MA, Chuquet J, Liaudet N, Bhaukaurally K, Santello M, Bouvier D, Tiret P, Volterra A. Local Ca2+ detection and modulation of synaptic release by astrocytes. Nat Neurosci. 2011 Sep 11;14(10):1276-84. doi: 10.1038\/nn.2929. PMID: 21909085.&nbsp;<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u3000\u6c38\u702c\u5c06\u5fd7&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.nt1dw7o6lwz_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.nt1dw7o6lwz\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.nt1dw7o6lwz\"><\/a>2010\u5e749\u670821\u65e5<\/h2>\n\n\n\n<p>NeuroClub\u306e\u7686\u69d8<\/p>\n\n\n\n<p>9\/28\u306eNeuroClub\u306f\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>The Journal of Neuroscience, July 28, 2010 &amp;#8226; 30(30):10048 &amp;#8211;10060<\/p>\n\n\n\n<p>Rapid Activation of Dormant Presynaptic Terminals by<\/p>\n\n\n\n<p>Phorbol Esters<\/p>\n\n\n\n<p>Chun Yun Chang, Xiaoping Jiang, Krista L. Moulder, and Steven Mennerick<\/p>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u3000\u6cb3\u91ce\u6d0b\u5e78<\/p>\n\n\n\n<p>&#8230;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.5ucv6fmyarz3_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5ucv6fmyarz3\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.5ucv6fmyarz3\"><\/a>2010\u5e749\u670821\u65e5<\/h2>\n\n\n\n<p>NeuroClub\u306e\u7686\u69d8<\/p>\n\n\n\n<p>9\/21\u306b\u521d\u62c5\u5f53\u306e\u8fbb\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4ee5\u4e0b\u306e\u8ad6\u6587\u3092\u3054\u7d39\u4ecb\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Progressive loss of phasic, but not tonic, GABA(A) receptor-mediated<\/p>\n\n\n\n<p>inhibition in dentate granule cells in a model of post-traumatic epilepsy in<\/p>\n\n\n\n<p>rats.<\/p>\n\n\n\n<p>Pavlov I, Huusko N, Drexel M, Kirchmair E, Sperk G, Pitk&amp;auml;nen A, Walker<\/p>\n\n\n\n<p>MC.<\/p>\n\n\n\n<p>Neuroscience. 2011 Aug 4.<\/p>\n\n\n\n<p>PMID:21840377<\/p>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u5b66\u7814\u7a76\u5ba4<\/p>\n\n\n\n<p>\u8fbb\u3000\u6075<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.roq94eoopdgh_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.roq94eoopdgh\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.roq94eoopdgh\"><\/a>2010\u5e746\u670830\u65e5<\/h2>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u5b66\u30fb\u89e3\u5256\u5b66\u306e\u7686\u69d8<\/p>\n\n\n\n<p>&nbsp;\u6765\u90316\u670830\u65e5\u306eNeuro Club\u62c5\u5f53<\/p>\n\n\n\n<p>\u795e\u7d4c\u751f\u7406\u306e\u5ca9\u702c\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u8ad6\u6587<\/p>\n\n\n\n<p>Science. 2008 Aug 1;321(5889):702-5.<\/p>\n\n\n\n<p>The cell and molecular basis of mechanical, cold, and inflammatory pain.<\/p>\n\n\n\n<p>Abrahamsen B, Zhao J, Asante CO, Cendan CM, Marsh S, Martinez-Barbera JP, Nassar MA, Dickenson AH, Wood JN.<\/p>\n\n\n\n<p><a href=\"http:\/\/www.sciencemag.org\/cgi\/content\/full\/321\/5889\/702\" target=\"_blank\" rel=\"noreferrer noopener\">http:\/\/www.sciencemag.org\/cgi\/content\/full\/321\/5889\/702<\/a><\/p>\n\n\n\n<p>\u3092\u4e2d\u5fc3\u306b\u3001\uff11\u6b21\u611f\u899a\u795e\u7d4c\u7dda\u7dad\u3068\u75bc\u75db\u4f1d\u9054\u8def\u306e\u8a71\u3092\u3054\u7d39\u4ecb\u3055\u305b\u3066\u9802\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p>\uff0asupplemental figure\u304c\u591a\u3081\u3067\u3059<\/p>\n\n\n\n<p>\u5b9c\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h.ja0ds2o39mp6_l\"><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ja0ds2o39mp6\"><\/a><a href=\"https:\/\/sites.google.com\/view\/jikei-neuroclub2024\/wednesday-journal-club?authuser=0#h.ja0ds2o39mp6\"><\/a>2010\u5e746\u670814\u65e5<\/h2>\n\n\n\n<p>NeuroClub\u53c2\u52a0\u8005\u306e\u7686\u69d8<\/p>\n\n\n\n<p>\u4eca\u9031\u306eNC\u3092\u62c5\u5f53\u3044\u305f\u3057\u307e\u3059\u795e\u7d4c\u751f\u7406\u306e\u9ad8\u6a4b\u3067\u3059\u3002<\/p>\n\n\n\n<p>\u4eca\u56de\u3001\u3054\u7d39\u4ecb\u3059\u308b\u8ad6\u6587\u3092\u9001\u4ed8\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>Borst JG. The low synaptic release probability in vivo. Trends Neurosci. 2010 Jun;33(6):259-66. doi: 10.1016\/j.tins.2010.03.003. Epub 2010 Apr 3. PMID: 20371122.&nbsp;<\/p>\n\n\n\n<p>\u3088\u308d\u3057\u304f\u304a\u9858\u3044\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u9ad8\u6a4b&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\uff08\u9014\u4e2d\u629c\u3051\u3066\u3044\u307e\u3059\u304c\u6f38\u6b21\u66f8\u304d\u8fbc\u307f\u307e\u3059\uff09 2023-12-27 \u85ac\u7406\uff1a\u77f3\u5ddd\u592a\u90ce\u5148\u751f \u660e\u65e5\u306eNeuroClub\u3067\u306f\u4e0b\u8a18\u306e\u8ad6\u6587\u3092\u7d39\u4ecb\u3057\u307e\u3059\u3002 Fos\u306e\u767a\u73fe\u306f\u3001\u305d\u306e\u7d30\u80de\u306e\u767a\u706b\u3067\u306f\u306a\u304f\u3001mGluR\u306a\u3069\u306b\u3088\u308bGq\u306e\u6d3b\u6027\u5316\u304c\u5fc5\u8981\u3060\u3068\u3044&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-92","page","type-page","status-publish","hentry"],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/92","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=92"}],"version-history":[{"count":5,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/92\/revisions"}],"predecessor-version":[{"id":505,"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=\/wp\/v2\/pages\/92\/revisions\/505"}],"wp:attachment":[{"href":"https:\/\/neuroclub.jikei-neuroscience.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=92"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}